ACUTE INFLAMMATORY RESPONSE TO A FOREIGN BODY IN Calomys callosus
DOI:
https://doi.org/10.5216/cab.v9i2.1211Keywords:
Sanidade animal, Saúde PublicaAbstract
Calomys callosus are wild rodents present in the Brazilian savannas that were adapted to the laboratorial conditions. These animals are resistant to infections that induce chronic inflammatory responses (Trypanosoma cruzi and Paracoccidioides brasiliensis). The objective of this work was to characterize the acute inflammatory reaction, prompted by the subcutaneous implementation of a foreign body. Twenty seven C. callosus and thirty B10A mice received implant and were comparatively analyzed during 144 hours. Circular cover slides implanted in C. callosus showed predominance of macrophages and eosinophils whereas in the mice, the neutrophils followed by the macrophages were the migratory dominant cells (p <0.05). It was concluded that C. callosus present inflammatory mechanisms for the removal of foreign body different from the ones found in the other rodents as well as in the human beings.
KEY WORDS: Acute inflammation, cover slip, granuloma, histology, wild rodents.
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