Avaliação comparativa dos efeitos tóxico-genéticos da própolis em células somáticas de Drosophila melanogaster, portadoras de diferentes níveis de enzimas de metabolização

Authors

  • Igor Gomes Oliveira Universidade Federal de Goiás
  • Karla Castro Pereira Universidade Federal de Goiás
  • Carolina Costa Guimarães Universidade Federal de Goiás
  • Torquato Naves Moraes Universidade Federal de Goiás
  • Lee Chen Chen Universidade Federal de Goi´s
  • Kênya Silva Cunha Universidade Federal de Goiás

DOI:

https://doi.org/10.5216/rbn.v4i1.4658

Keywords:

Anticitotóxico, Drosophila melanogaster, mutagênese, própolis, teste SMART

Abstract

This study aimed to evaluate the genotoxic and anti-cytotoxic activities of propolis on mitomycin C (MMC) induced lesions using Drosophila melanogaster strains with different cytochrome P-450 metabolic enzymes expression levels. The wing somatic mutation and recombination test (SMART) was used and supplied a wide spectrum of information concerning genic and cromossomal mutations and/or genetic recombinations. The results indicated that propolis acted as a direct modulator on cytotoxic effects induced by MMC. Furthermore, it was demonstrated that propolis did not induce mutagenic and/or recombinagenic events in D. melanogaster somatic cells. The data showed in this paper corroborates the ones described in the literature, contributing to determine the protective activity of propolis when administrated with genotoxic agents presenting different mechanisms of action.

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Published

2008-09-29

How to Cite

OLIVEIRA, I. G.; PEREIRA, K. C.; GUIMARÃES, C. C.; MORAES, T. N.; CHEN CHEN, L.; CUNHA, K. S. Avaliação comparativa dos efeitos tóxico-genéticos da própolis em células somáticas de Drosophila melanogaster, portadoras de diferentes níveis de enzimas de metabolização. Revista de Biologia Neotropical / Journal of Neotropical Biology, Goiânia, v. 4, n. 1, p. 64–69, 2008. DOI: 10.5216/rbn.v4i1.4658. Disponível em: https://revistas.ufg.br/RBN/article/view/4658. Acesso em: 22 nov. 2024.

Issue

Vol. 4 No. 1 (2007)

Section

Articles

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