Lack of mutagenicity of Solanum paniculatum L. in somatic cells of Drosophila melanogaster: SMART/wing

Authors

  • Vivian Ribeiro
  • Iara Lúcia Barbosa Fernandes Vieira
  • Débora Cristina Silva dos Passos
  • Elayne Miguel da Silva
  • Camila Regina do Vale
  • Leandro Prado Felício
  • Heleno Dias Ferreira
  • Pabline Marinho Vieira
  • Salvador de Carvalho

DOI:

https://doi.org/10.5216/rbn.v6i2.12851

Keywords:

Drosophila melanogaster, genotoxicity, jurubeba, SMART/wing, Solanum paniculatum L

Abstract

The lyophilized aqueous extract of Solanum paniculatum L. (jurubeba) leaves, a medicinal plant widely used by people as diuretic, in liver and spleen treatments, against fever and inflammation, underwent the SMART/wing test in somatic cells of Drosophila melanogaster for the evaluation of its mutagenic potential. We used three different concentrations of the leaf extract (2.5 mg.mL-1, 6.25 mg.mL-1, and 10 mg.mL-1), doxorubicin (DXR) as positive control, and distilled water with  5% sucrose as negative control. We employed three lineages of Drosophila in this experiment, flr³, ORR, and mwh. The  larvae derived from the standard cross (ST: flr³ females x mwh males) and the high bioactivation cross (HB: ORR females x mwh males) were chronically treated and the wings of the  emerging adults were analyzed. Our results showed no  mutagenic activity of S. paniculatum L. ST or HB crosses.

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Published

2010-12-29

How to Cite

RIBEIRO, V.; VIEIRA, I. L. B. F.; PASSOS, D. C. S. dos; SILVA, E. M. da; VALE, C. R. do; FELÍCIO, L. P.; FERREIRA, H. D.; VIEIRA, P. M.; CARVALHO, S. de. Lack of mutagenicity of Solanum paniculatum L. in somatic cells of Drosophila melanogaster: SMART/wing. Revista de Biologia Neotropical / Journal of Neotropical Biology, Goiânia, v. 6, n. 2, p. 27–33, 2010. DOI: 10.5216/rbn.v6i2.12851. Disponível em: https://revistas.ufg.br/RBN/article/view/12851. Acesso em: 20 dec. 2024.

Issue

Vol. 6 No. 2 (2009)

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