Proteínas de fase aguda em coelhos submetidos à colecistectomia laparoscópica – LigaSure versus eletrocirúrgico

Ana Clara Silva Machado; Mônica Carolina Nery Wittmaack; Maria Camila Maldonado Vera; Daniela Gomes da Silva; Guillherme Sembenelli; Gabriel Luiz Montanhim; Cléber Kazuo Ido; Juliana de Oliveira Ribeiro; Mareliza Possa de Menezes; Paola Castro Moraes

doi:10.1590/1809-6891v25e-79416E

Authors

Ana Clara Silva Machado Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0009-0004-8455-3901
Mônica Carolina Nery Wittmaack Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0001-7191-2320
Maria Camila Maldonado Vera Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-0979-0825
Daniela Gomes da Silva Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-5232-9516
Guillherme Sembenelli Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-3912-6423
Gabriel Luiz Montanhim Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-9830-041X
Cléber Kazuo Ido Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0003-2167-6010
Juliana de Oliveira Ribeiro Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-5393-7476
Mareliza Possa de Menezes Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-0294-5126
Paola Castro Moraes Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-0255-2971

DOI:

https://doi.org/10.1590/1809-6891v25e-79416E

Abstract

Studies have demonstrated that the LigaSure device causes less tissue damage than bipolar electrosurgery. Increases and decreases in protein and immunoglobulin concentrations after laparoscopic cholecystectomy are expected and transient. This study aimed to compare serum values of acute-phase proteins and immunoglobulins in rabbits undergoing gallbladder dissection using bipolar electrosurgery (Maryland forceps) and vessel sealing device (VSD) LigaSure. The objective was to determine which method resulted in less inflammatory change. Twenty rabbits were divided into two groups of ten each. Group 1 underwent laparoscopic cholecystectomy with bipolar electrosurgical forceps for dissection and LigaSure for sealing the cystic duct. Group 2 underwent dissection and cystic duct sealing using VSD–LigaSure only. Acute-phase proteins and immunoglobulins were evaluated on postoperative days three, seven, and fifteen. Serum concentrations of fibrinogen, transferrin, IgG, α1-acid glycoprotein, PM 23000 Da, and C-reactive protein (CRP) did not differ significantly between groups. However, significant differences were observed between evaluation days within the same group. IgA, ceruloplasmin, and haptoglobin were not statistically analyzed for either group or day comparisons. Only albumin levels differed between groups, with group 1 showing a lower protein concentration on day 15. Both methods caused changes in acutephase proteins, indicating no significant advantage for using the LigaSure device.

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