Therapeutic potential of otological formulations composed from Triticum aestivum, Bixa orellana, Tris-EDTA and N-acetylcysteine in the treatment of canine otitis externa

Authors

Abstract

The objective was to evaluate the efficiency of three otological solutions based on plant
extracts and adjuvants in treating canine otitis externa. Three different ear solutions were developed,
composed of ethanolic extracts of Triticum aestivum, Bixa orellana, and Tris-EDTA, ethanolic extracts
of Triticum aestivum, Bixa orellana, and N-acetylcysteine, and a combination of Triticum aestivum, Bixa
orellana, N-acetylcysteine, and Tris-EDTA. A commercial product was used as the control. The study
included 64 dogs diagnosed with otitis externa, randomly divided into four groups, treated once daily
for seven days. Clinical signs of otalgia, pruritus, odor, erythema, and cerumen amount were evaluated
on days D0, D3, and D7. Samples for bacterial, fungal cultures, and cytology were collected before
and after treatments. Clinical signs were scored from 0 to 3, with a sum generated per animal and
group during each evaluation day. All evaluated compounds effectively reduced clinical signs and
microorganisms involved in canine external otitis cases.

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Author Biographies

Renato Vianna, Universidade Católica de Pelotas (UCPel), Pelotas, Rio Grande do Sul, Brasil

Professor at the Department of Pharmacy and Biochemistry at the Catholic University of Pelotas - UCPEL

Fábio Raphael Pascoti Bruhn, Universidade Federal de Pelotas (UFPEL), Pelotas, Rio Grande do Sul, Brasil

Adjunct professor at the Federal University of Pelotas (UFPel), linked to the Department of Preventive Veterinary Medicine at the Faculty of Veterinary Medicine. Advisor professor of the postgraduate veterinary program and the postgraduate program in microbiology and parasitology at UFPel. Graduated in veterinary medicine and PhD in veterinary sciences, in the area of ​​Public Health and Animal Health from the Federal University of Lavras (UFLA). He works mainly in the area of ​​epidemiology applied to public, animal and environmental health.

Márcia de Oliveira Nobre, Universidade Federal de Pelotas (UFPEL), Pelotas, Rio Grande do Sul, Brasil

    clear       ​           629 / 5.000   Resultados de tradução Resultado da tradução Graduated in Veterinary Medicine from the Federal University of Pelotas (1984), master's degree in Veterinary Medicine from the Federal University of Pelotas (1997) and PhD in Veterinary Sciences from the Federal University of Rio Grande do Sul (2004) and post-doctorate at the Federal University of Pelotas (2005). She is currently a professor and advisor in the Postgraduate Veterinary Program at the Federal University of Pelotas. She has experience in the field of Veterinary Medicine, with an emphasis on small animal clinical medicine, development of therapeutic products and animal-mediated interventions (activity, education and therapy)

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Published

2024-10-04

How to Cite

BRITO, R. S. A. de; FREITAS, G. B. de; JÚNIOR, A. G. de A.; FREITAG, R. A.; VIANNA, R.; BRUHN, F. R. P.; JORGE, S.; NOBRE, M. de O. Therapeutic potential of otological formulations composed from Triticum aestivum, Bixa orellana, Tris-EDTA and N-acetylcysteine in the treatment of canine otitis externa. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 25, 2024. Disponível em: https://revistas.ufg.br/vet/article/view/78543. Acesso em: 23 nov. 2024.

Issue

Vol. 25 (2024): Publicação continua

Section

MEDICINA VETERINÁRIA

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