SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS

Authors

  • Sérgio Diniz Garcia Unesp
  • Silvia Helena Venturoli Perri Unesp
  • Gilberto Chierice Universidade de São Paulo
  • Daniel Cardoso Agência Paulista de Tecnologia do Agronegócio

DOI:

https://doi.org/10.5216/cab.v10i1.1660

Keywords:

Toxicologia

Abstract

Castor oil polymer is a biomaterial that can be used to fill bone defects. Biomaterials should present some characteristics such as: biocompatibility, inert, absence of toxin radical and vapour discharge and permit the organism to recognize them as a part of their structure. The aim of this study was to investigate changes in water ingestion, feed intake, weight gain and toxic effects in rats (Rattus norvegicus) after ingestion of 0, 10, 25 and 50% of castor oil polymer (COP, Ricinus communis). In groups that received 10 and 25% of COP the weight gain was smaller than the control group. Feed intake in control group was greater than in groups 10 and 50% COP. The intake of castor oil polymer reduced feed intake and water ingest probably because of the palatability of the product. In the second part of this study (multigenerational) there were no toxic effects in the offspring, as external birth defects or alterations incompatible with life, in spite of the fact that lower weight were observed in males and females of the second generation.

KEY WORDS: Biomaterials, bone defects, polymer, Ricinus communis.

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Author Biographies

Sérgio Diniz Garcia, Unesp

Professor Assistente de Doutor do Departamento de Clínica, Cirurgia e Reprodução Animal – FMVA/Unesp – Araçatuba, SP

Silvia Helena Venturoli Perri, Unesp

Professor Assistente de Doutor do Departamento de Apoio, Produção e Saúde Animal – FMVA/Unesp – Araçatuba, SP.

Gilberto Chierice, Universidade de São Paulo

Professor Titular

Universidade de São Paulo

São Carlos, SP.

Daniel Cardoso, Agência Paulista de Tecnologia do Agronegócio

Pesquisador Científico – APTA - Pólo Regional Extremo Oeste, UPD Araçatuba, SP.

Correspondência para o autor: danielcardoso@aptaregional.sp.gov.brFone/Fax: 18 3623 0447

 

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Published

2009-04-03

How to Cite

GARCIA, S. D.; PERRI, S. H. V.; CHIERICE, G.; CARDOSO, D. SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 10, n. 1, p. 219–225, 2009. DOI: 10.5216/cab.v10i1.1660. Disponível em: https://revistas.ufg.br/vet/article/view/1660. Acesso em: 22 nov. 2024.

Issue

Vol. 10 No. 1 (2009)

Section

Veterinary Medicine

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