Histomorphological and immunophenotypic diagnoses of gastrointestinal stromal tumors and other sarcomas that affect the intestine of dogs

Marina Laudares Costa; Felipe Augusto Ruiz Sueiro; Paulo César Jark; Leonardo Lamarca de Carvalho; Marcela Aldrovani Rodrigues; Vinícius Thomaz da Silva Almeida; Fernanda Gosuen Gonçalves Dias

doi:10.1590/1809-6891v24e-75610E

Autores

Marina Laudares Costa Universidade de Franca (UNIFRAN), Franca, São Paulo, Brasil https://orcid.org/0000-0002-3895-3523
Felipe Augusto Ruiz Sueiro VETPAT Laboratório de Análises Clínicas, Campinas, SP, Brasil https://orcid.org/0000-0001-8524-479X
Paulo César Jark Serviço de Oncologia Oncospes, Ribeirão Preto, São Paulo, Brasil https://orcid.org/0000-0001-7042-7235
Leonardo Lamarca de Carvalho Universidade de Franca (UNIFRAN), Franca, São Paulo, Brasil https://orcid.org/0000-0002-3730-2964
Marcela Aldrovani Rodrigues Universidade de Franca (UNIFRAN), Franca, São Paulo, Brasil https://orcid.org/0000-0002-5734-3042
Vinícius Thomaz da Silva Almeida Universidade de Franca (UNIFRAN), Franca, São Paulo, Brasil https://orcid.org/0000-0003-4030-5864
Fernanda Gosuen Gonçalves Dias Universidade de Franca (UNIFRAN), Franca, São Paulo, Brasil https://orcid.org/0000-0001-6072-4789

DOI:

https://doi.org/10.1590/1809-6891v24e-75610E

Resumo

Tendo em vista a semelhança morfológica entre tumores estromais gastrointestinais (GIST) e outros sarcomas do intestino de cães, objetivou-se realizar o diagnóstico histomorfológico e imunoistoquímico desses tumores, associando raça, sexo e idade, localização e invasão tumoral. Foram avaliados 217 casos por histopatologia e incluídos 36 diagnosticados por imuno-histoquímica (24 GIST e 12 outros sarcomas intestinais). Cães sem raça definida foram os mais diagnosticados com GIST, principalmente fêmeas idosas (9,5±2,2 anos); nos demais sarcomas intestinais, mestiços e Dachshunds, machos e fêmeas, foram igualmente acometidos. O ceco foi o mais acometido pelos GISTs, com invasão tumoral das camadas intestinais em todos os casos. O intestino delgado foi o mais acometido pelos demais sarcomas intestinais, com invasão das camadas na maioria desses tumores. GISTs expressaram marcadores como CD117 e DOG-1, ao contrário de outros sarcomas intestinais. O GIST e outros sarcomas intestinais denotaram características histomorfológicas e imunofenotípicas semelhantes à histopatologia, justificando a associação da imuno-histoquímica para o diagnóstico definitivo.
Palavras-chave: CD117; DOG-1; GIST; oncologia veterinária

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