EVALUATION OF OXIDATIVE STRESS IN PLASMA OF DAIRY COWS WITH MASTITIS

Authors

  • Cecilia Gabriela Rubert Possenti Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, ceciliapossenti@yahoo.com.br
  • Roberta Cattaneo Horn Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, rcattaneo@unicruz.edu.br http://orcid.org/0000-0001-9258-8005
  • Natacha Cossettin Mori Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, natachamori@msn.com
  • Vanderlei Ribas Junior Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, vanderleisrjj@hotmail.com
  • Diego Pascoal Golle Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, dgolle@unicruz.edu.br http://orcid.org/0000-0002-5264-8007
  • Jana Koefender Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, http://orcid.org/0000-0002-5882-9669

DOI:

https://doi.org/10.1590/cab19039754

Abstract

Bovine mastitis is associated with an endogenous antibacterial response mediated by the production of reactive species. However, excess oxidative reactions can trigger cellular apoptosis, aggravating the clinical state of the animals. In this context, the objective of this study was to evaluate the plasma redox response of dairy cows with and without mastitis submitted or not to antibiotic therapy. The cows were divided into control group (G1), cows without mastitis; group G2, cows with mastitis without antimicrobial treatment; group G3, cows with mastitis treated with antibiotics. Blood samples were collected after the first milking of the morning. The existence of lipoperoxidation (LPO) and the levels of carbonylated proteins (CPs), reduced glutathione (GSH), ascorbic acid (ASA), and uric acid (UA) were analyzed. The G3 animals showed increase in LPO and CPs. In all groups GSH levels were unchanged. Plasma ASA and AU values were decreased in the G2 and G3 groups. The results demonstrated that antimicrobial treatment seems to aggravate the oxidative damages present in bovine mastitis, reinforcing the importance of the search for therapeutic alternatives in order to minimize this effect.
Keywords: antibiotics; cellular oxidation; cows.

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Author Biographies

Cecilia Gabriela Rubert Possenti, Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, ceciliapossenti@yahoo.com.br

http://lattes.cnpq.br/3978692062558198

Roberta Cattaneo Horn, Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, rcattaneo@unicruz.edu.br

http://lattes.cnpq.br/4282856921907832

Natacha Cossettin Mori, Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, natachamori@msn.com

http://lattes.cnpq.br/0150811064822484

Vanderlei Ribas Junior, Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, vanderleisrjj@hotmail.com

 http://lattes.cnpq.br/4408867717909462

Diego Pascoal Golle, Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil, dgolle@unicruz.edu.br

http://lattes.cnpq.br/4193267565056836

Jana Koefender, Universidade de Cruz Alta, Cruz Alta, Rio Grande do Sul, Brasil,

http://lattes.cnpq.br/9334507519758004

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Published

2018-04-25

How to Cite

GABRIELA RUBERT POSSENTI, C.; CATTANEO HORN, R.; COSSETTIN MORI, N.; RIBAS JUNIOR, V.; PASCOAL GOLLE, D.; KOEFENDER, J. EVALUATION OF OXIDATIVE STRESS IN PLASMA OF DAIRY COWS WITH MASTITIS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 19, p. 1–9, 2018. DOI: 10.1590/cab19039754. Disponível em: https://revistas.ufg.br/vet/article/view/e-39754. Acesso em: 24 nov. 2024.

Issue

Vol. 19 (2018): Continuous publication

Section

MEDICINA VETERINÁRIA

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