Monitoring comparison of anaesthetised healthy sheep submitted to four different intraabdominal pressures

Liana Villela de Gouvea; Paulo Roberto Loureiro do Nascimento; Thiago Ravache Sobreira Leite; André Luís de Souza Teixeira; Paulo César do Amaral Ribeiro da Silva; José Aurelino Damasceno Ferreira Filho; Michel José Sales Abdalla Helayel; Amary Nascimento Júnior; Marina Galindo Chernard; Luiza de Albuquerque Carvalho; Pedro Leme Silva; Daniel Augusto Barroso Lessa

doi:10.1590/1809-6891v26e-78844E

Authors

Liana Villela de Gouvea Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0001-7109-0734
Paulo Roberto Loureiro do Nascimento Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0002-4487-8099
Thiago Ravache Sobreira Leite Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0002-5584-8231
André Luís de Souza Teixeira Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0002-4178-8581
Paulo César do Amaral Ribeiro da Silva Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0003-2883-6822
José Aurelino Damasceno Ferreira Filho Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brasil https://orcid.org/0000-0003-0804-8626
Michel José Sales Abdalla Helayel Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0002-7954-3221
Amary Nascimento Júnior Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0002-5042-3656
Marina Galindo Chernard Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0003-0819-6776
Luiza de Albuquerque Carvalho Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0002-7465-4213
Pedro Leme Silva Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil https://orcid.org/0000-0001-5838-4949
Daniel Augusto Barroso Lessa Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil https://orcid.org/0000-0002-7123-8265

DOI:

https://doi.org/10.1590/1809-6891v26e-78844E

Abstract

The sheep model is used for a variety of laparoscopy studies, as well as in routine procedures such as oocyte aspiration and artificial insemination. However, little information is published about the monitoring parameters and ventilatory mechanics changes and when they begin to occur during these procedures with pneumoperitoneum. Ten adult, healthy, non-pregnant Santa Inês sheep were anesthetized and mechanically ventilated (VT, 15 ml kg−1; positive end-expiratory pressure, 3 cmH₂O; FiO₂, 1.0), randomized in a crossover design for 4 different intra-abdominal pressures (IAP) as treatments: 0 mmHg (G1), 10 mmHg (G2), 12 mmHg (G3) and 15 mmHg (G4), for 60 min, with data collected every 10 min (HR, SpO₂, body temperature, ETCO₂, SAP, DAP, MAP, MACinsp, MACexp, Ppeak,_RS, V_T and Cdyn). End-expiratory CO₂ tension (ETCO₂) increased over time in all groups, except in G1. Peak airway pressure (Ppeak) and dynamic compliance (Cdyn) increased over time in all groups but were significantly higher in G3 and G4 from 20 min onwards. The minimum alveolar concentration (MAC) during inspiration and expiration increased over time in all groups, except G1. Within 20 minutes of the procedure, it was possible to notice that in the groups with higher IAP (G3 and G4) there was an increase in Ppeak and Cdyn, compatible with other findings of clinical importance such as an increase in ETCO₂, a decrease in V_T and SpO₂. Therefore, 20 minutes after the procedure, monitoring must be more careful, especially in animals with previous health conditions.

Downloads

Download data is not yet available.

References

Chemonges S, Shekar K, Tung JP, et al. Optimal Management of the Critically Ill: Anaesthesia, Monitoring, Data Capture, and Point-of-Care Technological Practices in Ovine Models of Critical Care. BioMed Research International. https://doi.org/10.1155/2014/468309.

Ewoldt JM, Anderson DE, Hardy J, Weisbrode SE. Evaluation of a Sheep Laparoscopic Uterine Trauma Model and Repeat Laparoscopy for Evaluation of Adhesion Formation and Prevention with Sodium Carboxymethylcellulose. Veterinary Surgery. 2004;33(6):668-672. https://doi.org/10.1111/j.1532-950x.2004.04090.x.

Galatos AD. Anesthesia and Analgesia in Sheep and Goats. Veterinary Clinics of North America: Food Animal Practice. 2011;27(1):47-59. https://doi.org/10.1016/j.cvfa.2010.10.007.

Teixeira PPM, Cristina L, Franco ME, Ferguson T, Souza LF. Aspiração Folicular por Videolaparoscopia em Ovelhas Santa Inês: Descrições da Técnica. Revista Científica Eletrônica de Medicina Veterinária. 2011;16. https://faef.revista.inf.br/imagens_arquivos/arquivos_destaque/wxtbZN2Du27xvTe_2013-6-25-17-3-12.pdf.

Padilha L, Teixeira P, Pires-Buttler E, et al. In vitro Maturation of Oocytes from Santa Ines Ewes Subjected to Consecutive Sessions of Follicular Aspiration by Laparoscopy. Reprod Dom Anim. 2014;49(2):243-248. https://doi.org/10.1111/rda.12261.

Scott J, Singh A, Valverde A. Pneumoperitoneum in Veterinary Laparoscopy: A Review. Veterinary Sciences. 2020;7(2):64. https://doi.org/10.3390/vetsci7020064.

do Nascimento PRL, de Gouvêa LV, Leite TRS, et al. Cardiorespiratory effects of different intraabdominal pressures in sheep: An experimental study. Physiological Reports. 2022;10(21). https://doi.org/10.14814/phy2.15506.

Percie du Sert N, Ahluwalia A, Alam S, et al. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. Boutron I, ed. PLoS Biol. 2020;18(7):e3000411. https://doi.org/10.1371/journal.pbio.3000411.

Massone F. Anestesiologia veterinária: farmacologia e técnicas: texto e atlas colorido. Grupo Gen - Guanabara Koogan; 2011. Accessed August 8, 2022. http://site.ebrary.com/id/10707354.

Mariano RSG, Uscategu RAR, Nociti RP, et al. Comparison of two surgical approaches for Laparoscopic Ovum Pick Up in Ewes. Arq Bras Med Vet Zootec. 2019;71(3):848-856. https://doi.org/10.1590/1678-4162-10336.

Neudecker J, Sauerland S, Neugebauer E, et al. The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery. Surg Endosc. 2002;16(7):1121-1143. https://doi.org/10.1007/s00464-001-9166-7.

Novitsky YW. Advantages of Mini-laparoscopic vs Conventional Laparoscopic Cholecystectomy: Results of a Prospective Randomized Trial. Arch Surg. 2005;140(12):1178. https://doi.org/10.1001/archsurg.140.12.1178.

Rodrigues JC, Teixeira-Neto FJ, Cerejo SA, et al. Effects of pneumoperitoneum and of an alveolar recruitment maneuver followed by positive end-expiratory pressure on cardiopulmonary function in sheep anesthetized with isoflurane–fentanyl. Veterinary Anaesthesia and Analgesia. 2017;44(4):841-853. https://doi.org/10.1016/j.vaa.2016.05.017.

Tranquilli WJ, Thurmon JC, Grimm KA, Lumb WV, eds. Lumb & Jones’ Veterinary Anesthesia and Analgesia. 4th ed. Blackwell Pub; 2007.

De Gouvêa LV, Leite TRS, Do Nascimento PRL, et al. Postprocedural clinical and laboratory evaluation of sheep submitted to different intrabdominal pressures during laparoscopy. Small Ruminant Research. 2023;228:107092. https://doi.org/10.1016/j.smallrumres.2023.107092.

Jo YY, Lee KC, Chang YJ, Jung WS, Park J, Kwak HJ. Effects of an Alveolar Recruitment Maneuver During Lung Protective Ventilation on Postoperative Pulmonary Complications in Elderly Patients Undergoing Laparoscopy. CIA. 2020;Volume 15:1461-1469. https://doi.org/10.2147/CIA.S264987.

Peake MD, Harabin AL, Brennan NJ, Sylvester JT. Steady-state vascular responses to graded hypoxia in isolated lungs of five species. Journal of Applied Physiology. 1981;51(5):1214-1219. https://doi.org/10.1152/jappl.1981.51.5.1214.

Morrell NW, Nijran KS, Biggs T, Seed WA. Magnitude and time course of acute hypoxic pulmonary vasoconstriction in man. Respiration Physiology. 1995;100(3):271-281. https://doi.org/10.1016/0034-5687(95)00002-U.

Wolf SJ, Reske AP, Hammermüller S, et al. Correlation of Lung Collapse and Gas Exchange - A Computer Tomographic Study in Sheep and Pigs with Atelectasis in Otherwise Normal Lungs. Staffieri F, ed. PLoS ONE. 2015;10(8):e0135272. https://doi.org/10.1371/journal.pone.0135272.

Prado Filho RR do, Sanches MC, Carregaro AB. Influence of recumbency on the pulmonary shunt in sevoflurane-anaesthetised sheep. Cienc Rural. 2022;52(11):e20210251. https://doi.org/10.1590/0103-8478cr20210251.

Wahba RWM, Tessler MJ, Kleiman SJ. Acute ventilatory complications during laparoscopic upper abdominal surgery. Canadian Journal of Anaesthesia. 1996;43(1):77-83. https://doi.org/10.1007/bf03015963.

Corrêa CMO, Brandão MJN, Hirata ES, Udelsmann A. Considerações anestésicas na cirurgia laparoscópica. ABCD, arq bras cir dig. 2008;21(3):136-138. https://doi.org/10.1590/S0102-67202008000300009.

Rauh R, Hemmerling TM, Rist M, Jacobi KE. Influence of pneumoperitoneum and patient positioning on respiratory system compliance. Journal of Clinical Anesthesia. 2001;13(5):361-365. https://doi.org/10.1016/S0952-8180(01)00286-0.

Lemos SL da S, Vinha JM, Silva IS, et al. Efeitos do pneumoperitônio com ar e CO2 na gasometria de suínos. Acta Cir Bras. 2003;18(5):445-451. https://doi.org/10.1590/S0102-86502003000500010.

Valenza F. Management of mechanical ventilation during laparoscopic surgery. Best Practice. Published online 2010:15. https://doi.org/10.1016/j.bpa.2010.02.002.

Atkinson TM, Giraud GD, Togioka BM, Jones DB, Cigarroa JE. Cardiovascular and Ventilatory Consequences of Laparoscopic Surgery. Circulation. 2017;135(7):700-710. https://doi.org/10.1161/CIRCULATIONAHA.116.023262.

Bellini L, Valentini A, Bernardini M. Comparison of the efficacy of two ventilatory strategies in improving arterial oxygen tension and content in anaesthetized sheep. Veterinary Anaesthesia and Analgesia. 2020;47(4):552-556. https://doi.org/10.1016/j.vaa.2020.02.008.

Myles PS. Bradyarrhythmias and Laparoscopy: A Prospective Study of Heart Rate Changes with Laparoscopy. Aust N Z J Obstet Gynaecol. 1991;31(2):171-173. https://doi.org/10.1111/j.1479-828X.1991.tb01811.x.

Cohen RV, Filho JCP, Schiavon CA, Correa JLL. Alterações Sistêmicas e Metabólicas da Cirurgia Laparoscópica. 2003;1:5. https://www.sobracil.org.br/revista/rv010102/rbvc010102_077.pdf.

Hikasa Y, Okuyama K, Kakuta T, Takase K, Ogasawara S. Anesthetic potency and cardiopulmonary effects of sevoflurane in goats: comparison with isoflurane and halothane. Can J Vet Res. 1998 Oct;62(4):299-306. PMID: 9798097; PMCID: PMC1189498.

Hikasa Y, Saito K, Takase K, Ogasawara S. Clinical, cardiopulmonary, hematological and serum biochemical effects of sevo¯urane and iso¯urane anesthesia in oxygen under spontaneous breathing in sheep. Small Ruminant Research. Published online 2000:9. https://doi.org/10.1016/S0921-4488(99)00121-2.

Koivusalo A ‐M., Lindgren L. Effects of carbon dioxide pneumoperitoneum for laparoscopic cholecystectomy. Acta Anaesthesiologica Scandinavica. 2000;44(7):834-841. https://doi.org/10.1034/j.1399-6576.2000.440709.x.