Injectable supplementation of butaphosphan through differents pharmaceutical forms on postpartum metabolism and milk production in dairy cows

Abstract

The aim of this study was to evaluate the effects of different pharmaceutical forms of
Butaphosphan on milk production and the metabolism in dairy cows during the postpartum period.
After in vitro and pharmacokinetic assays, thirty-six multiparous cows belonging to the Holstein breed,
were randomly divided into three groups: Group BUT (n=12), that received an aqueous solution of
Butaphosphan (150 mg/mL); Group BUTSR (n=12), that received a sustained-release formulation of
Butaphosphan (150 mg/mL) and Group Control (CL ; n=12), that received saline solution (NaCl 0.9
%). All the groups received three subcutaneous doses of 30 mL in the neck region, on the day of
parturition (day 0) and 3 and 7 days after parturition. Blood samples were collected on days 0, 3, 7 and
10, postpartum. Daily milk production was evaluated from day 11 to 60, postpartum. The animals of the
BUTSR group presented greater (P=0.01) milk production than the other groups. It was observed that
the BUTSR and BUT groups showed higher blood levels of calcium (P=0.01) than the animals in the CL
group. The BUTSR group obtained higher milk production compared to other groups, demonstrating
that this pharmaceutical form has great potential for a future product and could be an alternative
for the market. More studies are needed to better understand the action of Butaphosphan on the
metabolism of dairy cows in the recent postpartum period.