Metastatic extramedullary plasmacytoma in a canine
DOI:
https://doi.org/10.1590/1809-6891v24e-75186EAbstract
Plasmocytomas are neoplasms originating from malignant plasma cells and can be subdivided into cutaneous extramedullary, non-cutaneous and multiple myeloma. The involvement of vertebrae can generate clinical signs of pain and neurological alterations according to the affected segment, with the appearance of metastases being uncommon. The present study aims to report a case of extramedullary plasmacytoma with primary site in the thoracic vertebra and with consequent spinal cord compression and metastases, characterizing its clinicopathological aspects. The patient was hospitalized, submitted to laboratory and imaging tests, and medicated due to incoordination and loss of perception of limb positioning, but his clinical condition worsened, progressing to loss of movement and fecal and urinary incontinence, resulting in death. The main necropsy findings were the presence of a tumor mass along the external surface of the body of the fifth thoracic vertebra, in addition to light brown foci in the thoracic spinal cord and in the pulmonary and splenic parenchyma. Histologically, the tumor mass and light brown foci consisted of malignant cell proliferation, of plasmacytic origin, densely cellular and largely infiltrative. Thus, through the clinical picture presented, image exams and anatomopathological analysis, it was evidenced that it was a case of atypical extramedullary plasmocytoma, with metastasis in the spinal cord, lung and spleen.
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Silva C, Lara K, Andrade AC, Francisco GL, Guedes RL. Plasmocitoma extramedular em região perineal de cão–relato de caso. Biociências, Biotecnologia e Saúde Paraná. 2017;10(19):129-31.
Rakich, PM, Latimer, KS, Weiss, R, Steffens, WL. Mucocutaneous plasmacytomas in dogs: 75 cases (1980-1987). Journal of the American Veterinary Medical Association, 1989;194 (6), 803-810.
Clark, GN, Berg, J, Engler, SJ, Bronson, RT. Extramedullary plasmacytomas in dogs: results of surgical excision in 131 cases. American Animal Hospital Association (USA), 1992.
Morton LD, Barton CL, Elissalde GS, Wilson SR. Oral extramedullary plasmacytomas in two dogs. Veterinary Pathology, 1986, 23(5),637-639. Doi: 10.1177/030098588602300519
Barroco-Neto R, Mello C, Rocha A, Sembenelli G, Sueiro F, Jark P. Plasmocitoma ósseo solitário em cães: Relato de três casos. Ars Veterinaria. 2017;33(1):37-43. Doi: 10.15361/2175-0106.2017v33n1p37-43
Gorenstein T, Jark P, Feliciano M, Sueiro F, Anai L, Fenerich M, et al. Extramedullary plasmacytoma in the penile bulb of a dog: case report. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2016:292-8. Doi: 10.1590/1678-4162-8411
Wypij JM, de Lorimier LP. Surgery and radiation therapy for extramedullary plasmacytoma of the penile mucosa in a dog. Canadian Veterinary Journal, 2012;53(9):992.
Johnson J, Hung G, Larson V, Manasse J, Spotswood T. Renal extramedullary plasmacytoma in a dog. Canadian Veterinary Journal, 2021;62(10):1077. Doi: (10):1077-1082.
Ipek V, Acar H, Kocaturk M, Salci H, Sonmez G. Extramedullary pulmonary plasmacytoma in a dog. Acta Veterinaria Brno, 2019;69(2):244-50. Doi: 10.2478/acve-2019-0020
Trevor P, Saunders G, Waldron D, Leib M. Metastatic extramedullary plasmacytoma of the colon and rectum in a dog. Journal of the American Veterinary Medical Association, 1993;203(3):406-9.
Vail DM, Thamm DH, Liptak JM. Hematopoietic tumors. In: Vail DM, Thamm DH, Liptak JM. Withrow and MacEwen's Small animal clinical oncology. 6ed. St Louis: Elsevier; 2019, p. 688.
Milken VMF, Cursino LH, Menegon FG, Parisi GG, Braga KM, Medeiros-Ronchi AA. Intradural Extramedullary Plasmacytoma in a Dog. Acta Scientiae Veterinariae, 2020;48. Doi:10.22456/1679-9216.97756
Feitosa FLF. Exame Físico Geral ou de Rotina. In: Feitosa FLF. Semiologia Veterinária, a arte do diagnóstico. 4ed. Rio de Janeiro; Roca; 2020.
Tappin SW, Taylor SS, Tasker S, Dodkin SJ, Papasouliotis K, Murphy KF. Serum protein electrophoresis in 147 dogs. Veterinary Record, 2011,168(17), 456–456. Doi:10.1136/vr.d88
Meuten D, Sample S. Laboratory Evaluation and Interpretation of the Urinary System. In: Thrall MA, Weiser G, Alisson RW, Campbell TW. Veterinary Hematology, Clinical Chemistry, and Cytology. Wiley Blackwell, 2022. p. 343-401.
Hayes‐Lattin B, Blanke CD, Deloughery TG. Pulmonary and intracerebral plasmacytomas in a patient without multiple myeloma: a case report. American Journal of Hematology, 2003;73(2):131-4. Doi: 10.1002/ajh.10330
Cangul I, Wijnen M, Van Garderen E, Van Den Ingh T. Clinico‐pathological aspects of canine cutaneous and mucocutaneous plasmacytomas. Journal of Veterinary Medicine Series A, 2002;49(6):307-12. Doi: 10.1046/j.1439-0442.2002.00456.x
Majzoub M, Breuer W, Platz S, Linke R, Hermanns W. Histopathologic and immunophenotypic characterization of extramedullary plasmacytomas in nine cats. Veterinary Pathology, 2003;40(3):249-53. Doi: 10.1354/vp.40-3-249
Hendrick MJ. Mesenchymal Tumors of the Skin and Soft Tissues. In: Meuten DJ. Ed.Tumors in domestic animals. 5ed. John Wiley; Sons; 2016. p. 142-175.
Santoro MB, Bahr Arias MV. Complicações observadas em cães e gatos com doenças neurológicas. Pesquisa Veterinária Brasileira, 2018;38:1159-71. Doi: 10.1590/1678-5150-PVB-4968
Lorenz MD, Kornegay JN. Neurologia veterinária. Barueri: Manole; 2006. p.467.
Thrall ED. Diagnóstico de Radiologia Veterinária. Rio de Janeiro: Elsevier; 2014. p.131-175.
Stockham SL, Scott MA. Leucócitos. In: Stockham SL, Scott MA. Ed. Fundamentos de Patologia Clínica Veterinária. Rio de Janeiro: Guanabara Koogan; 2011. p. 45-89.
Madan S, Dispenzieri A, Lacy MQ, Buadi F, Hayman SR, Zeldenrust SR, et al. Clinical features and treatment response of light chain (AL) amyloidosis diagnosed in patients with previous diagnosis of multiple myeloma. Mayo Clinic Proceedings, 2010. Doi: 10.4065/mcp.2009.0547
Sternberg R, Wypij JM, Barger AM. Extramedullary and solitary osseous plasmacytomas in dogs and cats. Veterinary Medicine, 2009;104(10):477-9.
Adelman L, Larson V, Sissener T, Spotswood T. Extramedullary plasmacytoma in the lung of a Doberman pinscher dog. Canadian Veterinary Journal, 2014;55(1):1237. Doi: 10.2478/acve-2019-0020
Wang J, Pandha H, Treleaven J, Powles R. Metastatic extramedullary plasmacytoma of the lung. Leuk Lymphoma, 1999;35(3-4):423-5. Doi: 10.3109/10428199909145749
Rusbridge C, Wheeler SJ, Lamb CR, Page RL, Carmichael S, Brearley MJ, et al. Vertebral plasma cell tumors in 8 dogs. Journal of Veterinary Internal Medicine, 1999;13(2):126-33. Doi: 10.1892/0891-6640(1999)013<0126:vpctid>2.3.co;2
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