Seroprevalence and risk factors associated with leukosis in cattle from Villlavicencio, Colombia
DOI:
https://doi.org/10.1590/1809-6891v24e-74298EAbstract
Bovine leukosis is caused by an oncogenic virus of the genus Deltaretrovirus, causing losses associated with decreased production indicators and restrictions on exports of cattle and cattle products. The disease has a prolonged incubation period of between 1–5 years and the antibodies can be detected 2–3 weeks post infection. The disease can present asymptomatically, and develop persistent lymphocytosis or lymphosarcoma. The objective of this study was to estimate the prevalence and risk factors associated with bovine leukosis in Villavicencio, Colombia. Blood samples were taken from 636 animals, and obtained randomly from 24 herds. The samples were analysed using a Competition ELISA kit for the detection of anti-gp51 antibodies. Information on possible risk factors was collected, then OR and X2 were calculated, and statistically significant with p < 0.05 variables were included in a linear regression multivariate analysis. The general seroprevalence was 24.6% and the herd seroprevalence was 83.3%. The seroprevalence was 21.3% in males and 25.0% in females. The risk factors identified were abortion, non-bearing cows, artificial insemination, and use of common needles, Creole breed and participation in cattle exhibitions. The study confirmed the presence of bovine leukosis associated with reproductive and management factors.
Keywords: bovine persistent lymphocytosis; bovine lymphoma; bovine chronic infectious viruses; bovine leukosis; ELISA.
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Bartlett PC, Ruggiero VJ, Hutchinson HC, Droscha CJ, Norby B, Sporer KR, Taxis T. M. Current developments in the epidemiology and control of enzootic bovine leukosis as caused by bovine leukemia virus. Pathogens. 2020; 9(12): 1058. Disponível em:: 10.3390/pathogens9121058
Polat M, Takeshima SN, Aida Y. Epidemiology and genetic diversity of bovine leukemia virus. Virology Journal. 2017; 14(1): 1-16. Available from:10.1186/s12985-017-0876-4.
Schwartz I, Levy D. Pathobiology of bovine leukemia virus. Veterinary Research. 1994; 25(6): 521-536. Available from:https://pubmed.ncbi.nlm.nih.gov/7889034/.
Kuczewski A, Orsel K, Barkema HW, Mason S, Erskine R, Van der Meer F. Invited review: Bovine leukemia virus—Transmission, control, and eradication. Journal of Dairy Science. 2021; 104(6): 6358-6375. Available from:10.3168/jds.2020-18925.
Ruiz V, Porta NG, Lomónaco M, Trono K, Alvarez I. Bovine leukemia virus infection in neonatal calves. Risk factors and control measures. Frontiers in Veterinary Science. 2018; 5: 267. Available from:10.3389/fvets.2018.00267.
Delarmelina E, Buzelin MA, Souza BSD, Souto FM, Bicalho JM, Câmara RJF, Reis J KPD. High positivity values for bovine leukemia virus in human breast cancer cases from Minas Gerais, Brazil. PLoS One. 2020; 15(10): e0239745. Available from:10.1371/journal.pone.0239745.
Khatami A, Pormohammad A, Farzi R, Saadati H, Mehrabi M, Kiani SJ, Ghorbani S. Bovine Leukemia virus (BLV) and risk of breast cancer: a systematic review and meta-analysis of case-control studies. Infectious Agents and Cancer. 2020: 15(1): 1-8. Available from:10.1186/s13027-020-00314-7.
Federación Colombiana de Ganaderos (FEDEGAN). Situación en Colombia de enfermedades bovinas no sujetas a control oficial recopilación de resultados diagnósticos 2005-2009. Bogotá DC: FEDEGAN. 2010.
ICA Censo Pecuario Nacional. Instituto Colombiano Agropecuario. Bogotá DC: ICA; 2016. [cited 2022 June 1]. Available from: <https://www.ica.gov.co/Areas/Pecuaria/Servicios/Epidemiologia-Veterinaria/Censos-2016/Censo-2017.aspx.>. Accessed: June 10, 2021.
Dohoo I, Martin W, Stryhn H. Veterinary epidemiologic research. 2 nd. Canada: VER Inc. 2003. 865p. English.
Bulla-Castañeda DM, Díaz-Anaya AM, Garcia-Corredor DJ, Pulido-Medellín MO. Serodiagnosis of paratuberculosis in cattle of the municipality of Sogamoso, Boyacá (Colombia). Entramado. 2020; 16(2): 312-320. Available from:http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S1900-38032020000200312
LaDronka RM, Ainsworth S, Wilkins MJ, Norby B, Byrem TM, Bartlett PC. Prevalence of bovine leukemia virus antibodies in US dairy cattle. Veterinary Medicine International. 2018. Available from:10.1155/2018/5831278.
Nekouei O, VanLeeuwen J, Sanchez J, Kelton D, Tiwari A, Keefe G. Herd-level risk factors for infection with bovine leukemia virus in Canadian dairy herds. Preventive Veterinary Medicine. 2015; 119(3-4): 105-113. Available from: 10.1016/j.prevetmed.2015.02.025.
Şevik M, Avcı O, İnce ÖB. An 8-year longitudinal sero-epidemiological study of bovine leukaemia virus (BLV) infection in dairy cattle in Turkey and analysis of risk factors associated with BLV seropositivity. Tropical Animal Health and Production, 2015; 47(4): 715-720. Disponível em:: 10.1007/s11250-015-0783-x.
Mousavi S, Haghparast A, Mohammadi G, Tabatabaeizadeh S. Prevalence of bovine leukemia virus (BLV) infection in the northeast of Iran. Veterinary Research Forum. 2014; 5(2):135-9. PMID: 25568707, PMCID: PMC4279628
Murakami K, Kobayashi S, Konishi M, Kameyama KI, Yamamoto T, Tsutsui T. The recent prevalence of bovine leukemia virus (BLV) infection among Japanese cattle. Veterinary Microbiology. 2011; 148(1); 84-88. Available from:10.1016/j.vetmic.2010.08.001.
Hassan NAD, Mohteshamuddin K, Anthony A, Al Aiyan A, Mohamed ME, Abdalla Alfaki IM, Barigye R. Serological evidence of enzootic bovine leukosis in the periurban dairy cattle production system of Al Ain, United Arab Emirates. Tropical Animal Health and Production. 2020: 52(5): 2327-2332. Available from:10.1007/s11250-020-02262-1.
Selim A, Marawan MA, Ali AF, Manaa E, AbouelGhaut HA. Seroprevalence of bovine leukemia virus in cattle, buffalo, and camel in Egypt. Tropical Animal Health and Production. 2019; 52(3): 1207-1210. Available from:10.1007/s11250-019-02105-8.
Resoagli JP, Jacobo RA, Storani CA, Cipolini MF, Stamatti GM, Deco M, Alfonzo D. Seroprevalencia de leucosis enzootica bovina en rodeos de cria de la provincia de Corrientes, Argentina. Revista de Medicina Veterinaria-Buenos Aires. Revista de Medicina Veterinaria-Buenos Aires. 2001; 82(2): 71-73.
Ramalho GC, Silva MLCR, Falcão BMR, Limeira CH, Nogueira DB, Dos Santos AM. de Azevedo SS. High herd-level seroprevalence and associated factors for bovine leukemia virus in the semi-arid Paraíba state, Northeast Region of Brazil. Preventive Veterinary Medicine. 2021; 190: 105324. Disponível em:: 10.1016/j.prevetmed.2021.105324.
Moraes MP, Weiblen R, Flores EF, Oliveira JCD, Rebelatto MC, Zanini M, Pereira NM. Levantamento sorológico da infecção pelo vírus da leucose bovina nos rebanhos leiteiros do estado do Rio Grande do Sul, Brasil. Ciência Rural. 1996; 26(2): 257-262. Available from:10.1590/S0103-84781996000200015.
Carneiro PAM, Araújo WPD, Birgel EH, Souza KWD. Prevalência da infecção pelo vírus da leucose dos bovinos em rebanhos leiteiros criados no Estado do Amazonas, Brasil. Acta Amazonica. 2003; 33: 111-125. Available from:10.18041/1900-3803/entramado.2.6758
Grau MA, Monti G. Prevalencia serológica predial e intrapredial para el virus de la leucosis bovina (VLB) en lecherías de las regiones de Los Ríos y de Los Lagos de Chile. Archivos de Medicina Veterinaria, 2010; 42(2): 87-91. Available from:10.4067/S0301-732X2010000200010.
Rojas JLC, Martinez FA, Tarazona A, Cepeda BM. Prevalencia de la seropositividad a la leucosis bovina mediante la técnica diagnóstica de ELISA indirecta en hatos lecheros situados en Mesa de los Santos, Santander. Spei Domus. 2009; 5(11): 6-11. Available from:https://repository.ucc.edu.co/handle/20.500.12494/9821.
Ortiz OD, Sánchez A, Tobón J, Chaparro Y, Cortés S, Gutiérrez MA. Seroprevalence and risk factors associated with bovine leukemia virus in Colombia. Journal of Veterinary Medicine and Animal Health. 2016; 8(5): 35-43. Available from:doi:10.5897/JVMAH2016.0457
Erskine RJ, Bartlett PC, Byrem TM, Render CL, Febvay C, Houseman JT. Association between bovine leukemia virus, production, and population age in Michigan dairy herds. Journal of Dairy Science. 2012; 95(2):727-734. Available from:10.3168/jds.2011-4760.
Kirkbride CA. Etiologic agents detected in a 10-year study of bovine abortions and stillbirths. Journal of Veterinary Diagnostic Investigation. 1992; 4(2): 175-180. Available from:10.1177/104063879200400210.
Betancur C, Rodas J. Seroprevalencia del virus de la leucosis viral bovina en animales con trastornos reproductivos de Montería. Revista MVZ. 2008;13(1): 1197-1204. Available from:http://www.scielo.org.co/scielo.php?script=sci_artt
ext&pid=S0122-02682008000100011
Blagitz MG, Souza FN, Batista CF, Azevedo LFF, Sanchez ER, Diniz SA, Della Libera AMMP. Immunological implications of bovine leukemia virus infection. Research in Veterinary Science. 2017; 114: 109-116. Available from:10.1016/j.rvsc.2017.03.012.
Sledge DG, Maes R, Wise A, Kiupel M, Fitzgerald SD. Coinfection of a cow with bovine leukemia virus and Mycobacterium bovis. Journal of Veterinary Diagnostic Investigation. 2009; 21(6): 878-882. Disponível em:: 10.1177/104063870902100621.
Kuczewski A, Orsel K, Barkema HW, Mason S, Erskine R, Van der Meer F. Invited review: Bovine leukemia virus—Transmission, control, and eradication. Journal of Dairy Science. 2021; 104(6): 6358-6375. Available from:10.3168/jds.2020-18925.
Khamesipour F, Doosti A, Shahraki AK, Goodarzi M. Molecular detection of bovine leukemia virus (BLV) in the frozen semen samples of bulls used for artificial insemination in Iran. Research Opinions in Animal and Veterinary Sciences. 2013; 3(11): 412-416. Available from: https://www.cabdirect.org/cabdirect/abstract/20133383804
Choi KY, Monke D, Stott, JL. Absence of bovine leukosis virus in semen of seropositive bulls. Journal of Veterinary Diagnostic Investigation. 2002; 14(5); 403-406. Available from:10.1177/104063870201400507.
Wrathall AE, Simmons HA, Van Soom A. Evaluation of risks of viral transmission to recipients of bovine embryos arising from fertilisation with virus-infected semen. Theriogenology. 2006; 65(2): 247-274. Available from:10.1016/j.theriogenology.2005.05.043.
Benavides B, Monti G. Assessment of Natural Transmission of bovine leukemia virus in dairies from southern Chile. Animals (Basel). 2022; 12(13):1734. Available from:10.3390/ani12131734.
Benitez OJ, Roberts JN, Norby B, Bartlett PC, Maeroff JE, Grooms DL. Lack of Bovine leukemia virus transmission during natural breeding of cattle. Theriogenology. 2019;1(126): 187-190. Available from:10.1016/j.theriogenology.2018.12.005
Hutchinson HC, Norby B, Erskine RJ, Sporer KRB, Bartlett PC. Herd management practices associated with bovine leukemia virus incidence rate in Michigan dairy farms. Preventive Veterinary Medicine. 2020; 182: 105084. Available from:https://doi.org/10.1016/j.prevetmed.2020.105084
Weber AF, Meiske JC, Haggard DL, Sorensen DK, Domagala AM, Flaum AM. Failure to demonstrate transmission of enzootic bovine leukemia virus infection from cows to sheep by use of common injection needles. American Journal of Veterinary Research. 1988; 49(11): 1814-1816. PMID: 2854706
Casal J, Learte P, Torre EA. A path model of factors influencing bovine leukemia virus transmission between cattle herds. Preventive Veterinary Medicine. 1990; 10(1-2): 47-61. Available from:10.1016/0167-5877(90)90050-R
Udina IG, Karamysheva EE, Turkova SO, Orlova AR, Sulimova GE. Genetic mechanisms of resistance and susceptibility to leukemia in Ayrshire and black pied cattle breeds determined by allelic distribution of gene Bola-DRB3. Russian Journal of Genetics. 2003; 39(3): 306-317. Available from:10.1023/A:1023279818867
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