Good practices in the rearing and maintenance of zebrafish (Danio rerio) in Brazilian laboratories
Abstract
Good Laboratory Practice (GLP) is a management quality control system that encompasses the organizational process and conditions under which non-clinical health and environmental studies are carried out. According to the World Health Organization, GLP must contain five topics: resources, characterization, rules, results, and quality control. The aim of this work is to address a review according to WHO standard to the implementation of Good Laboratory Practices in zebrafish (Danio rerio) facility. Considering that the promotion of one health (animal, human, and environmental) associated with an education plan, protocols, and records are fundamental to guarantee the safety and integrity of employees, animals and the environment as well as reliability in the results generated. In a way, Brazil still needs improvements related to the wellfare of aquatic organisms (national laws, international agreements, corporate programs, and others); especially in relation to its use in research and technological development. In this way, the implementation of GLPs provide valuable guidance for improving animal welfare and worker safety, facilitating the standardization of research.
Keywords: Danio rerio; standardization; welfare; regulatory guidelines; legislation.
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