Aplicação de antioxidantes naturais na reprodução animal

Camila da Silva Castro; Carlos Filipe Camilo Cotrim; Igor Romeiro dos Santos; Klayto José Gonçalves dos Santos; Joelma Abadia Marciano de Paula; Samantha Salomão Caramori; Luciane Madureira de Almeida; Elisa Flávia Luiz Cardoso Bailão; Leonardo Luiz Borges

doi:10.1590/1809-6891v23e-73601E

Authors

Camila da Silva Castro Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil https://orcid.org/0000-0002-8309-7981
Carlos Filipe Camilo Cotrim Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil https://orcid.org/0000-0001-8173-5110
Igor Romeiro dos Santos Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil https://orcid.org/0000-0002-4249-7639
Klayto José Gonçalves dos Santos Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil https://orcid.org/0000-0002-9761-2606
Joelma Abadia Marciano de Paula Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil https://orcid.org/0000-0003-0737-2600
Samantha Salomão Caramori Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil https://orcid.org/0000-0003-2676-8280
Luciane Madureira de Almeida Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil https://orcid.org/0000-0003-1764-1480
Elisa Flávia Luiz Cardoso Bailão https://orcid.org/0000-0001-6737-7548
Leonardo Luiz Borges Universidade Estadual de Goiás (UEG), Anápolis, Goiás, Brasil and Pontifícia Universidade Católica de Goiás (PUC-GO), Goiânia, Goiás, Brasil. https://orcid.org/0000-0003-2183-3944

DOI:

https://doi.org/10.1590/1809-6891v23e-73601E

Abstract

Antioxidants are natural or synthetic substances that delay oxidation through one or more mechanisms, such as scavenging free radicals, inhibiting lipid peroxidation, and complexing with metals, inhibiting tissue destruction via oxidation. Antioxidants are commonly used in animal feed and the food industry to prevent the oxidation of animal-origin products. Moreover, natural oxidants are used increasingly in animal reproduction, especially for semen preservation. In this context, this study aimed to review the applications of natural antioxidants in animal reproduction. We observed that the bulk of the natural antioxidants, approximately 80.4%, were commercially acquired and used mainly for semen cooling/freezing (72%) with promising results (90%) in Sus scrofa (boar), Capra aegagrus hircus (goat), Gallus gallus domesticus (rooster), and Ovis aries (ram). However, further studies are needed to help determine the appropriate dosage of natural antioxidants for applications.
Keywords: cryopreservation; free radicals; lipid peroxidation; oxidative stress; vitamin E.

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References

Ugbogu EA, Elghandour MMMY, Ikpeazu VO, Buendía GR, Molina OM, Arunsi OM, Arunsi UO, Emmanuel O, Salem AZM. The potential impacts of dietary plant natural products on the sustainable mitigation of methane emission from livestock farming. J. Clean. Prod. 2019; 213: 915-925.

Martelli F, Nunes FMF. Radicais livres: em busca do equilíbrio. Ciência e Cultura, São Paulo. 2014; 66(3): 54-57.

Rahman I, Biswas SK, Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol. 2006; 533:222-39.

Rajendrasozhan S, Yang SR, Edirisinghe I, Yao H, Adenuga D, Rahman I. Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD. Antioxid Redox Signal. 2008; 10(4):799-811.

Poli G, Leonarduzzi G, Biasi F, Chiarpotto E. Oxidative stress and cell signalling, Curr. Med. Chem. 2004;11: 1163-82.

Vasconcelos TB, Cardoso ARNR, Josino JB, Macena RHM, Bastos VPD. Radicais Livres e Antioxidantes: Proteção ou Perigo? Cient Ciênc Biol Saúde. 2014; 16(3):213-9.

Tort L. Stress and imune modulation in fish. Dev. Comp. Immunol. 2011; 35:1366-75.

Schneider CD, Oliveira AR. Radicais livres de oxigênio e exercício: mecanismo de formação e adaptação ao treinamento físico. Revista Brasileira de Medicina do Esporte. 2004; 10: 303-13.

Jiménez MH, Cerrila MEO, Peralta MC, Haro JGH, Díazcruz A, Perrusquía RG. Estrés oxidativo y el uso de antioxidantes en animales domésticos. Interciencia: Revista de Ciencia y Tecnología de América. 2005; 30: 728-34.

Oliveira RS, Lucas CB, Antonucci C, Silva SC. Natural Bioative Compounds: Promoting Agents in The Reduction of Oxidative Extress and Inflammatory Processes. South American Journal of basic education, technical en technological. 2018; 5(1):258-73.

Campigotto G, Alba DF, Sulzbach MM, Santos DS, Souza CF. Dog food production using curcumin as antioxidant: effects of intake on animal growth, health and feed conservation. Arch Anim Nutr. 2020; 74(5): 397-413.

Brazil, Food Ingredients. Dossiê Antioxidantes. Os antioxidantes. 2009; 6:16.

Lee MT, Lin WC, Yu B, Lee TT. Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals - A review. Asian-australas. J. Anim. Sci. 2017; 30(3): 299.

Carocho M, Morales P, Ferreira ICFR. Antioxidants: Reviewing the chemistry, food applications, legislation and role as preservatives. Trends Food Sci Technol. 2018; 71107- 120.

Wong FC, Xiao J, Wang S, Ee KY, Chai TT. Advances on the antioxidant peptides from edible plant sources. Trends Food Sci Technol. 2020; 99: 44-57.

Torres BP, Pires JS, Santos DYAC, Chow F. Ensaio do potencial antioxidante de extratos de algas através do sequestro do ABTS•+ em microplaca. Instituto de Biociências, Universidade de São Paulo – SP, 2017.

Zhong R, Zhou D. Oxidative Stress and Role of Natural Plant Derived Antioxidants in Animal Reproduction. J Integr Agric. 2013; 12(10): 1826-1838.

Mazur M, Zwyrzykowska-Wodzińska A, Wojtas E, Zachwieja A, Salejda AM. Effect of yerba mate (Ilex paraguariensis A.St.-Hil.) supplementation on oxidative stress in Ruminants. Chil. J. Agric. Res. 2019; 79(2).

Wu X, Zhou Q, Xu K. Are isothiocyanates potential anti-cancer drugs? Acta Pharmacologica Sinica, 2009; 30 (5): 501.

Manganaris GA, Goulas V, Vicente AR, Terry LA. Berry antioxidants: small fruits providing large benefits: Berry antioxidants: small fruits providing large benefits. Journal of the Science of Food and Agriculture. 2014: 94(5): 825 833.

Tiveron AP. Atividade antioxidante e composição fenólica de legumes e verduras consumidos no Brasil. Mestrado em Ciência e Tecnologia de Alimentos Piracicaba: Universidade de São Paulo – SP, 2010.

Zhang H, Yin M, Huang L, Wang J, Gong L, Liu J, Sun B. Evaluation of the cellular and animal models for the study of antioxidant activity: a review. Journal of Food Science. 2017; 82(2): 278-88.

Leão LL, Oliveira FS, Souza RS, Farias PKS, Da Fonseca FSA, Martins ER, De Souza RM. Uso de antioxidantes naturais em carnes e seus subprodutos. Caderno de Ciências Agrárias. 2017; 9(1): 94-100.

Damodaran S, Parkin K, Fennema O. Química de Alimentos de Fennema. Porto Alegre-RS: Artmed. 2008.

Gámez-Meza N, Noriega-Rodriguez JÁ, Medina-Juárez LA, Ortega-García J, Cázarez-Casanova R, Ângulo-Guerrero O. Antioxidant activity in soybean oil of extracts from Thompsons grape bagasse. Journal of the American Oil Chemists Society; 1999; 76(12): 1445-47.

Silva JB, Costa KMFM, Coelho WAC, Paiva KAR, Costa GAV, Salatino A, Freitas CIA, Batista JS. Quantificação de fenóis, flavonoides totais e atividades farmacológicas de geoprópolis de Plebeia aff. Flavocincta do Rio Grande do Norte. Pesquisa Vet Braz. 2016; 36(9): 874 880.

Sucupira NR, Silva AB, Pereira G, Costa JN. Métodos Para Determinação da Atividade Antioxidante de Frutos. UNOPAR Cient Ciênc Biol Saúde. 2012; 14(4):263-9.

Silveira AC, Kassuia YS, Domahovski RC, Lazzarotto M. Método de DPPH adaptado: uma ferramenta para analisar atividade antioxidante de polpa de frutos da erva-mate de forma rápida e reprodutível. Comunicado Técnico 421. EMBRAPA Colombo-PR, 2018.

Pulido, R.; Bravo, L.; Saura-Calixto, F. Antioxidant activity of dietary as determined by modified ferric reducing/antioxidant power assay. Journal Agriculture and Food Chemistry. 2000; 48(8): 3396-3402.

Rufino MSM, Alves RE, Brito ES, Sampaio CG, Pérez-Jiménez J, Saura-Calixto FD. Metodologia Científica: Determinação da Atividade Antioxidante Total em Frutas pelo Método de Redução do Ferro (FRAP). Comunicado Técnico 125, Embrapa Agroindústria Tropical. 2006.

Rufino MSM, Alves RE, Brito ES, Sampaio CG, Pérez-Jiménez J, Saura-Calixto FD. Metodologia Científica: Determinação da Atividade Antioxidante Total em Frutas pela Captura do Radical Livre ABTS +. Comunicado Técnico 128, Embrapa Agroindústria Tropical. 2007a.

Duarte-Almeida JM, Santos RJ, Genovese MI, Lajolo FM. Avaliação da atividade antioxidante utilizando sistema β-caroteno/ácido linoléico e método de sequestro de radicais DPPH• Ciênc. Tecnol. Aliment., Campinas. 2006, 26(2): 446-452.

Rufino MSM, Alves RE, Brito ES, Sampaio CG, Pérez-Jiménez J, Saura-Calixto FD. Metodologia Científica: Determinação da Atividade Antioxidante Total em Frutas pela Captura do Radical Livre DPPH. Comunicado Técnico 127, Embrapa Agroindústria Tropical. 2007b.

Thaipong K, Boonprakob U, Crosby K, Cisneroszevallos L, Byrne DH. Comparison of ABTS, DPPH, FRAP and ORAC assays for estimatin g antioxidant activity from guava fruit extracts. J. Food Compos. Anal. 2006; 19: 669-75.

Ou B, Huang D, Hampsch-Woodil, M, Flanagan JA, Deemer EK. Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays: a comparative studyJ Agric Food Chem. 2002; 50: 3122–3128.

Lenardão EJ, Freitag RA, Dabdoub MJ, Silveira CC. “Green chemistry” – os 12 princípios da química verde e sua inserção nas atividades de ensino e pesquisa. Quim. Nova 2003; 26, 1: 123-129.

Doble M, Rollinsk, Kumar A. Green Chemistry and Engineering 2007.

Chien T, Liu C, Chang Y, Fang C, Pai Juo-Hsiang, Wu Y, Chen S. Therapeutic effects of herbal-medicine combined therapy for COVID-19: A systematic review and meta-analysis of randomized controlled trials. Front. Pharma. 2022; 13.

Prasathkumar M, Anischa S, Dhrisya C, Robert Becky R, Sadhasivam S. Therapeutic and pharmacological efficacy of selective Indian medicinal plants – A review. Phytom. Plus 2021; 1.

Joly CA, Scarano FR, Bustamante M, Gadda TMC, Metzger JPW, Seixas CS, Ometto JPHB, Pires APF, Boesing AL, Sousa FDR, Quintão JMB, Gonçalves LR, Padgurschi MCG, Aquino MFS, Castro PFD. Brazilian assessment on biodiversity and ecosystem services: summary for policy makers. Biota Neotrop. 2019; 19, 4.

Souza FP, Castilho TPR, Macedo LOB. An institutional framework for Bioinputs in Brazilian agriculture based on Ecological Economics. Sust. Debate 2022; 13, 1.

Potts RJ, Notarianni LJ, Jefferies TM. Seminal plasma reduces exogenous oxidative damage to human sperm, determined by measurement of DNA strand breaks and lipid peroxidation. Mutation Research. 2000; 447: 249-256.

Arguello FAPB, Zervoudakis LKH, Zervoudakis JT, Duarte Júnior MF, Tsuneda PP, Marinho WAS, Silva LES, Moraes JO, Barbosa EA. Efeito da suplementação oral de selênio e tocoferol sobre a membrana plasmática espermática em touros da raça Brangus. Rev. Bras. Cienc. Vet. 2017; 24(3):157-161.

Pezo F, Yest M, Zambrano FA, Uribe P, Risopatrona J, Sanchez R. Antioxidants and their effect on the oxidative/nitrosative stress of frozen-thawed boar sperm. Cryobiology. 2021; 98: 5-11.