Fechamento de defeitos em padrão de figura geométrica associado ao emprego de anestesia por tumescência com lidocaína em coelhos (Oryctolagus cuniculus)

Eduardo Luís Serafim; Josiane Morais Pazzini; Michelle do Carmo Pereira Rocha; Laís Calazans Menescal Linhares; Andrigo Barboza de Nardi; Maria de Fátima Moutinho Gartner; Irina Amorim; Alexandra Rema; Fátima Faria; Ricardo Andres Ramirez Uscategui; Vivian Tavares de Almeida; Carlos Alfredo Calpaa; Sabrina Gouveia Calazans

doi:10.1590/1809-6891v22e-7072e-70728

Authors

Eduardo Luís Serafim 1Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0001-9029-8709
Josiane Morais Pazzini 1Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-5406-5825
Michelle do Carmo Pereira Rocha 1Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0001-8362-5003
Laís Calazans Menescal Linhares Universidade Estadual Paulista "Júlio de Mesquita Filho" UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-6117-7366
Andrigo Barboza de Nardi 1Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0001-6463-2144
Maria de Fátima Moutinho Gartner Universidade do Porto (ICBAS-UP), Porto, Portugal https://orcid.org/0000-0002-5302-0086
Irina Amorim Universidade do Porto (ICBAS-UP), Porto, Portugal https://orcid.org/0000-0002-2305-1631
Alexandra Rema Universidade do Porto (ICBAS-UP), Porto, Portugal https://orcid.org/0000-0003-4319-2404
Fátima Faria Universidade do Porto (ICBAS-UP), Porto, Portugal https://orcid.org/0000-0002-7069-3696
Ricardo Andres Ramirez Uscategui Universidade Estadual Paulista "Júlio de Mesquita Filho" UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-9760-8631
Vivian Tavares de Almeida Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-1737-8611
Carlos Alfredo Calpaa Universidade de Natño, Colombia https://orcid.org/0000-0002-9188-6550
Sabrina Gouveia Calazans Universidade Estadual Paulista "Júlio de Mesquita Filho" UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0002-7704-8999

DOI:

https://doi.org/10.1590/1809-6891v22e-7072e-70728

Abstract

The use of tumescent anesthesia with lidocaine can provide better intra- and postoperative analgesia that would benefit extensive reconstructive surgery. However, lidocaine can interfere with the healing process. Therefore, this study aimed to assess the local interference of the healing of induced and closed skin defects in a geometric pattern associated with the use of tumescent anesthesia with lidocaine in rabbits. Furthermore, we assessed its influence on cardiorespiratory parameters and postoperative analgesia. This study included 27 rabbits divided into three groups: GC (without the use of tumescence), GS (use of tumescence with 0.9% NaCl solution), and GL (use of tumescent anesthesia with lidocaine). There was no statistically significant intergroup difference in any stage of the wound healing process on macroscopic evaluations, in the angiogenesis process, or in the process of collagenization and fibroblast deposition. There were significant differences in heart rate (lower in GL), respiratory rate (higher in GC), mean arterial pressure (higher in GL), and expired concentration of isoflurane (lower in GL). There was no significant intergroup difference in the von Frey filament test or the visual analog scale score used to evaluate postoperative analgesia. We concluded that tumescent anesthesia with lidocaine does not impair postoperative tissue repair. Its use features benefits such as reducing the volume of inhaled anesthetic, maintaining the anesthesia plan, stable heart and respiratory rates, and lower hypotension during the surgical procedure.
Keywords: Local anesthetic; Pain; Reconstructive surgery; Tissue repair

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