Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance

Authors

  • Danielle Storino Freitas Departamento de Engenharia de Biossistemas, Universidade Federal de São João del Rei. Praça Dom Helvécio, 74 - Dom Bosco, São João del-Rei, MG, 36301-160, Brazil https://orcid.org/0000-0002-2336-518X
  • Guilherme Antonio de Gouvêa Lopes Departamento de Engenharia de Biossistemas, Universidade Federal de São João del Rei. Praça Dom Helvécio, 74 - Dom Bosco, São João del-Rei, MG, 36301-160, Brazil https://orcid.org/0000-0002-8097-3237
  • Barbara Rodrigues Nascimento Departamento de Engenharia de Biossistemas, Universidade Federal de São João del Rei. Praça Dom Helvécio, 74 - Dom Bosco, São João del-Rei, MG, 36301-160, Brazil https://orcid.org/0000-0002-4579-0662
  • Luiza Aparecida Ansaloni Chagas Pereira Departamento de Ciências Naturais, Universidade Federal de São João del Rei. Praça Dom Helvécio, 74 - Dom Bosco, São João del-Rei, MG, 36301-160, Brazil https://orcid.org/0000-0001-5767-4936
  • Ribrio Ivan Tavares Pereira Batista Departamento de Ciências Biológicas, Universidade Estadual de Minas Gerais, Av. São Paulo (Rod MG 040 URB), 3996 - Vila Rosário, MG, 32412-190 https://orcid.org/0000-0003-4938-2655
  • Paulo Henrique Almeida Campos Junior Universidade Federal de São João Del Rei https://orcid.org/0000-0003-2400-2548

Abstract

Conjugated linoleic acid (CLA) is a mixture of positional isomers of linoleic acid found in meat and dairy products from ruminants. It is a trans fat widely used by athletes as a food supplement, due to a supposed effect of maximizing the use of body fat reserves. The interest in diet and culture media supplementation with CLA is an emerging area, demanding studies in order to elucidate its benefits in the reproductive parameters, as well as in cryopreservation. Therefore, the aim of this review was to discuss the effects of CLA on the oocytes, sperm and embryos cryotolerance. Some studies have already demonstrated its use in cryopreservation of germline. Among those, it was observed that CLA supplementation during oocyte in vitro maturation can increase their viability post-freezing and developmental capacity. Regarding the use of CLA on sperm, there are few studies and their results are still inconclusive. Finally, studies about CLA supplementation on embryo culture media have shown promising results, indicating that this bioactive molecule is able to modulate lipid uptake on blastomeres. Altogether, these findings demonstrate the potential use of CLA as a bioactive molecule to improve germline and embryo cryotolerance and open new perspectives on human and animal reproduction field.
Keywords: lipid accumulation, cryopreservation, embryo, oocyte, sperm.

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Published

2020-10-20

How to Cite

FREITAS, D. S.; LOPES, G. A. de G.; NASCIMENTO, B. R.; PEREIRA, L. A. A. C.; BATISTA, R. I. T. P.; ALMEIDA CAMPOS JUNIOR, P. H. Conjugated linoleic acid as a potential bioactive molecule to modulates gamete and embryo cryotolerance. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 21, 2020. Disponível em: https://revistas.ufg.br/vet/article/view/63574. Acesso em: 30 jun. 2024.

Issue

Vol. 21 (2020): Continuous publication

Section

MEDICINA VETERINÁRIA

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