Ácido linoleico conjugado como potencial bioativo para modulação e criotolerância de gametas e embriões

Danielle Storino Freitas; Guilherme Antonio de Gouvêa Lopes; Barbara Rodrigues Nascimento; Luiza Aparecida Ansaloni Chagas Pereira; Ribrio Ivan Tavares Pereira Batista; Paulo Henrique Almeida Campos Junior

doi:10.1590/1809-6891v21e-63574

Authors

Danielle Storino Freitas Universidade Federal de São João del-Rei (UFSF), São João del-Rei, Minas Gerais, Brasil https://orcid.org/0000-0002-2336-518X
Guilherme Antonio de Gouvêa Lopes Universidade Federal de São João del-Rei (UFSF), São João del-Rei, Minas Gerais, Brasil https://orcid.org/0000-0002-8097-3237
Barbara Rodrigues Nascimento Universidade Federal de São João del-Rei (UFSF), São João del-Rei, Minas Gerais, Brasil https://orcid.org/0000-0002-4579-0662
Luiza Aparecida Ansaloni Chagas Pereira Universidade Federal de São João del-Rei (UFSF), São João del-Rei, Minas Gerais, Brasil https://orcid.org/0000-0001-5767-4936
Ribrio Ivan Tavares Pereira Batista Universidade Federal de São João del-Rei (UFSF), São João del-Rei, Minas Gerais, Brasil https://orcid.org/0000-0003-4938-2655
Paulo Henrique Almeida Campos Junior Universidade Federal de São João del-Rei (UFSF), São João del-Rei, Minas Gerais, Brasil https://orcid.org/0000-0003-2400-2548

DOI:

https://doi.org/10.1590/1809-6891v21e-63574

Abstract

Conjugated linoleic acid (CLA) is a mixture of positional isomers of linoleic acid found in meat and dairy products from ruminants. It is a trans fat widely used by athletes as a food supplement, due to a supposed effect of maximizing the use of body fat reserves. The interest in diet and culture media supplementation with CLA is an emerging area, demanding studies in order to elucidate its benefits in the reproductive parameters, as well as in cryopreservation. Therefore, the aim of this review was to discuss the effects of CLA on the oocytes, sperm and embryos cryotolerance. Some studies have already demonstrated its use in cryopreservation of germline. Among those, it was observed that CLA supplementation during oocyte in vitro maturation can increase their viability post-freezing and developmental capacity. Regarding the use of CLA on sperm, there are few studies and their results are still inconclusive. Finally, studies about CLA supplementation on embryo culture media have shown promising results, indicating that this bioactive molecule is able to modulate lipid uptake on blastomeres. Altogether, these findings demonstrate the potential use of CLA as a bioactive molecule to improve germline and embryo cryotolerance and open new perspectives on human and animal reproduction field.
Keywords: lipid accumulation, cryopreservation, embryo, oocyte, sperm.

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