STUDY OF THE BEHAVIOR OF SERIC CREATINE KINASE (CK) AND CREATINE KINASE–MB (CK-MB) OF DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXIGENATION (ECMO) FOR THREE HOURS

Authors

  • Felipp Silveira Ferreira Universidade Estadual do Norte Fluminense Darcy Ribeiro
  • Lara Lages Silveira UENF
  • Alessandra Castello Costa
  • Antonio Peixoto Albernaz
  • Claudio Baptista Carvalho
  • André Lacerda Abreu Oliveira

DOI:

https://doi.org/10.5216/cab.v11i3.6197

Keywords:

Animal Sanity

Abstract

The extracorporeal membrane oxygenation (ECMO) is a technique of prolonged cardiopulmonary support, which aims to help the lungs or the heart when these organs present failure processes not responsive to conventional treatments. As it is not a physiological procedure, it represents a major challenge for medicine, which seeks to make it a safer procedure. Thus, this research was carried out to determine the course of the cardiac markers CK and CK-MB of five dogs submitted at ECMO for three hours. Mongrel dogs of various ages, weight and sex were used. Under anesthesic maintenance, the animals were subjected to femoral cannulation for ECMO, in an arterial-venous (AV) deviation. Once the circuit was established, the variables were measured every thirty minutes for a period of three hours. The data were statistically analyzed with Anova, Tukey and Pearson Correlation, with α = 5%. The results showed an increase of serum CK and CK-MB, characterizing a muscular injury during the procedure. The results showed that ECMO induced a cardiac muscle injury by a physiological mechanism. It was concluded that ECMO is a viable technical support and do not induce myocardial injury in dogs during a period of three hours.

KEYWORDS: CK, CK-MB, dogs, ECMO, physiology.

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Published

2010-10-02

How to Cite

FERREIRA, F. S.; SILVEIRA, L. L.; COSTA, A. C.; ALBERNAZ, A. P.; CARVALHO, C. B.; OLIVEIRA, A. L. A. STUDY OF THE BEHAVIOR OF SERIC CREATINE KINASE (CK) AND CREATINE KINASE–MB (CK-MB) OF DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXIGENATION (ECMO) FOR THREE HOURS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 11, n. 3, p. 705–712, 2010. DOI: 10.5216/cab.v11i3.6197. Disponível em: https://revistas.ufg.br/vet/article/view/6197. Acesso em: 17 may. 2024.

Issue

Vol. 11 No. 3 (2010)

Section

Veterinary Medicine

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