EVALUATION OF BLOOD BIOMARKERS CONCENTRATION IN EQUINES SUBMITTED TO EXPERIMENTAL OBSTRUCTION OF DUODENUM, ILEUM AND LARGE COLON

Authors

  • Paula Alessandra Di Filippo
  • Rodrigo Norberto Pereira Faculdade Integrada de Campo Mourão - PR.
  • João Henrique Perotta FCAV, Unesp, Jaboticabal, SP.
  • Maria Augusta Berlingieri FCAV, Unesp, Jaboticabal, SP.
  • Fernanda Coutinho de Freitas Faculdade de Ituverava "Dr. Francisco Maeda"- FAFRAM/SP.
  • Áureo Evangelista Santana FCAV, Unesp.

DOI:

https://doi.org/10.5216/cab.v12i1.5940

Keywords:

Animal sanity

Abstract

This study aimed to evaluate the parameters of renal and hepatic functions in horses submitted to an experimental model of intestinal obstruction. Twenty-four animals were distributed into four different groups: instrumented control (GI), duodenum obstruction (GII), ileum obstruction (GIII) and large colon obstruction (GIV). Blood samples were collected one hour before the surgical procedure (T0); 3 hours after the obstruction/ischaemia (T3i); and 1, 3, 12, 24, 72 and 120 hours after the beginning of reperfusion/deobstruction for determination of the concentration of urea, creatinine, aspartate aminotransferase, gamma glutamyl transferase, alkaline phosphatase, albumin, glucose, fibrinogen and bilirrubin (total, direct and indirect). During obstructive period none significant alterations were observed in the biochemical parameters evaluated. After the unblocking procedure, the animals from GII and GIII presented an increase in aspartate aminotransferase, alkaline phosphatase, fibrinogen and total and direct bilirrubin values. However, these changes were not associated with clinical signs of liver damage and, at the end of the observation period their values were found within normal range. Considering the laboratory tests for the diagnosis of hepatic lesions lack specificity, it is recommended that such tests are performed concomitantly and in series.
KEYWORDS: Acute abdomen, blood biomarkers, equines.

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Author Biographies

Paula Alessandra Di Filippo

Pós-graduanda do Departamento de Clinica e Cirurgia Veterinaria da FCAV, Unesp, Jaboticabal, SP.

Rodrigo Norberto Pereira, Faculdade Integrada de Campo Mourão - PR.

Professor de Clínica e Cirurgia de Grandes Animais da Faculdade Integrada de Campo Mourão - PR

João Henrique Perotta, FCAV, Unesp, Jaboticabal, SP.

Mestrando em cirugia veterinaria pelo Departamento de Clínica e Cirurgia Veterinária da FCAV/Unesp, Jaboticabal - SP.

Maria Augusta Berlingieri, FCAV, Unesp, Jaboticabal, SP.

Mestranda em cirugia veterinaria pelo Departamento de Clínica e Cirurgia Veterinária da FCAV/Unesp, Jaboticabal - SP.

Fernanda Coutinho de Freitas, Faculdade de Ituverava "Dr. Francisco Maeda"- FAFRAM/SP.

Professora de Higiene e Inspeção de Produtos de Origem Animal da Faculdade de Ituverava  "Dr. Francisco Maeda"- FAFRAM/SP.

Áureo Evangelista Santana, FCAV, Unesp.

Professor Adjunto do Departamento de Clínica e Cirurgia Veterinária da FCAV/Unesp, Jaboticabal - SP.

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Published

2011-03-31

How to Cite

DI FILIPPO, P. A.; PEREIRA, R. N.; PEROTTA, J. H.; BERLINGIERI, M. A.; FREITAS, F. C. de; SANTANA, Áureo E. EVALUATION OF BLOOD BIOMARKERS CONCENTRATION IN EQUINES SUBMITTED TO EXPERIMENTAL OBSTRUCTION OF DUODENUM, ILEUM AND LARGE COLON. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 12, n. 1, p. 178–186, 2011. DOI: 10.5216/cab.v12i1.5940. Disponível em: https://revistas.ufg.br/vet/article/view/5940. Acesso em: 21 nov. 2024.

Issue

Vol. 12 No. 1 (2011)

Section

Veterinary Medicine

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