THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II

Authors

  • Flávia Santin UNESP
  • Maria do Carmo Fernandez Vailati UNESP
  • Marcela Marcondes Pinto Rodrigues UNESP
  • David Michelucci UDESC
  • Luis Cuadrado Martin UNESP
  • Denise Saretta Schwartz USP

DOI:

https://doi.org/10.5216/cab.v11i4.4635

Keywords:

Animal Sanity

Abstract

Angiotensin II (ANGII) is a vasoconstrictor which action on inflammation has been studied. The objective of this study was to verify the stimulation of cyclooxigenase-2 and blood pressure on renal damage by ANGII. Wistar rats were distributed into four groups, as follows: group 1 – control; group 2 – ANGII; group 3 – ANGII + celecoxib; and group 4 – celecoxib. The ANGII was infused in the animals by subcutaneous osmotic mini-pumps during 72 hours. After that, euthanasia was performed. The blood pressure was measured before the drugs administration and before the euthanasia. Histopathological and immunohistochemical evaluations were performed in kidneys to assess the expression of COX-2. It was concluded that ANGII caused renal damage, regardless of blood pressure values. ANGII associated with celeboxib increased blood pressure. Celecoxib did not protect the kidneys against ANGII activities.

KEYWORDS: Blood pressure, celecoxib, nephrotoxicity.

Downloads

Download data is not yet available.

Author Biographies

Flávia Santin, UNESP

departamento de clínica veterinária

Maria do Carmo Fernandez Vailati, UNESP

departamento de clínica veterinária

Marcela Marcondes Pinto Rodrigues, UNESP

departamento de clínica veterinária

David Michelucci, UDESC

departamento de solos- estatística

Luis Cuadrado Martin, UNESP

departamento de clínica médica

Denise Saretta Schwartz, USP

Departamento de clínica médica

Downloads

Published

2010-12-21

How to Cite

SANTIN, F.; VAILATI, M. do C. F.; PINTO RODRIGUES, M. M.; MICHELUCCI, D.; MARTIN, L. C.; SCHWARTZ, D. S. THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 11, n. 4, p. 867–873, 2010. DOI: 10.5216/cab.v11i4.4635. Disponível em: https://revistas.ufg.br/vet/article/view/4635. Acesso em: 17 jul. 2024.

Issue

Vol. 11 No. 4 (2010)

Section

Veterinary Medicine

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).