EFFECTS OF CLONIDINE AND RILMENIDINE ON CARDIORESPIRATORY AND GASTROINTESTINAL SYSTEMS OF HORSES

Authors

  • José Edgard de Oliveira Alves Universidade Estadual do Norte Fluminense Darcy Ribeiro
  • Scarlath Ohana Penna dos Santos Universidade Estadual do Norte Fluminense
  • Fábio Sartori Universidade Severino Sombra
  • Marcelo Flores Catelli Universidade Severino Sombra

DOI:

https://doi.org/10.1590/cab17438488

Keywords:

Animal Sanity

Abstract

Clonidine and rilmenidine are drugs used in human medicine as central acting antihypertensive agents due to their actions on the alpha2-adrenoceptor and I1 imidazoline receptors in the central nervous system. Currently, clonidine is also used as a pre-anesthetic medication and in spinal anesthesia, and rilmenidine, despite the lower selectivity for alpha2-adrenergic receptors than clonidine, has also shown antinociceptive potential in experimental pain models. In this study, six horses were submitted to four treatments: R1 group (0.014 mg/kg of rilmenidine); R2 group (0.021 mg/kg of rilmenidine); Clo group (0.002 mg/kg of clonidine), and a control group. The assessment comprehended their heart and respiratory rates, systolic blood pressure and intestinal motility at basal levels and, then, 60 and 120 minutes after the oral administration of the drugs. Rilmenidine decreased heart rate on   the two tested doses, which did not occur in the clonidine treatment; slight variations in systolic blood pressure in all treatments and respiratory rate reduction in treatments with rilmenidine at 0.021 mg/ kg and clonidine at 0.002 mg/kg were also observed. Further studies with different dosages and varied administration routes are still necessary in order to elucidate more effects of these drugs on horses.

Keywords:    alfa2-adrenoceptor agonists; blood pressure; imidazolines; intestinal motility; pharmacology.

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Author Biographies

José Edgard de Oliveira Alves, Universidade Estadual do Norte Fluminense Darcy Ribeiro

Residente de Anestesiologia Veteterinária da Universidade Estadual do Norte Fluminense Darcy Ribeiro

Scarlath Ohana Penna dos Santos, Universidade Estadual do Norte Fluminense

Residente de Cirurgia de Pequenos Animais da Universidade Estadual do Norte Fluminense

Fábio Sartori, Universidade Severino Sombra

Professor da Universidade Severino Sombra

Marcelo Flores Catelli, Universidade Severino Sombra

Professor da Universidade Severino Sombra

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Published

2016-10-28

How to Cite

ALVES, J. E. de O.; SANTOS, S. O. P. dos; SARTORI, F.; CATELLI, M. F. EFFECTS OF CLONIDINE AND RILMENIDINE ON CARDIORESPIRATORY AND GASTROINTESTINAL SYSTEMS OF HORSES. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 17, n. 4, p. 608–614, 2016. DOI: 10.1590/cab17438488. Disponível em: https://revistas.ufg.br/vet/article/view/38488. Acesso em: 21 nov. 2024.

Issue

Vol. 17 No. 4 (2016)

Section

Veterinary Medicine

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