IMMUNOEXPRESSION OF TGF-? IN NORMAL CANINE PROSTATES AND WITH PROLIFERATIVE LESIONS

Authors

Abstract

Abstract
The transforming growth factor-? (TGF-?), a mediator of prostatic growth induces angiogenesis and
inhibits cell proliferation. It was used in this study in order to evaluate its expression in normal
prostatic tissue and those with benign proliferative lesions, pre-malignant and malignant prostatic
diseases. A total of 54 glands with normal histomorphology, epithelial benign prostatic hyperplasia
(BPH), stromal BPH, prostatic inflammatory atrophy (PIA), prostatic intraepithelial neoplasia (PIN),
and adenocarcinoma were selected and used in the tissue microarray block (TMA). The TMA slides
were subjected to the immunohistochemistry with anti-TGF-? and its staining intensity in epithelial
and stromal cells was evaluated. There was TGF-? immunostaining by both normal tissues and those with proliferative lesions. Higher TGF-? immunostaining was observed in cells from normal
prostatic tissues and with HPB, whereas prostatic cells with PIA, PIN and carcinoma exhibited lower
immunostaining of this cytokine, suggesting the action of TGF-? in the maintenance of normal
tissue homeostasis and with benign proliferative lesion and in the progression of pre-malignant and
malignant proliferative lesions of the canine prostate.
Keywords: carcinoma, immunohistochemistry, growth factor, PIA, PIN.

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Author Biographies

Denise Caroline Toledo, Universidade Federal de Goiás

Programa de Pós-graduação em Ciência Animal, Área de Patologia, Clínica e Cirurgia Animal, Escola de Veterinária e Zootecnia

Mariana Batista Rodrigues Faleiro, Universidade Federal de Goiás

Patologia animal

Hugo Henrique Ferreira, Universidade Federal de Goiás

Programa de Pós-graduação em Ciência Animal, Área de Patologia, Clínica e Cirurgia Animal, Escola de Veterinária e Zootecnia

Adriana Marques Faria, Universidade Federal de Goiás

Programa de Pós-graduação em Ciência Animal, Área de Patologia, Clínica e Cirurgia Animal, Escola de Veterinária e Zootecnia

Moema Pacheco Chediak Matos, Universidade Federal de Goiás

Professor Adjunto, Serviço de Patologia Veterinária, Departamento de Medicina veterinária e zootecnia da Universidade Federal de Goiás (EVZ-UFG).

Renee Laufer Amorim, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil.

Professor Adjunto, Serviço de Patologia Veterinária, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia (FMVZ),

Veridiana Maria Brianezi Dignani De Moura, Universidade Federal de Goiás

Professor Adjunto, Serviço de Patologia Veterinária, Departamento de Medicina veterinária e zootecnia da Universidade Federal de Goiás (EVZ-UFG). Campus II, Rodovia (GO 462) Goiânia-Nova Veneza km 0, CEP: 74001-970, Caixa Postal 131, Goiânia, GO, Brasil. Fone/Fax: 55 (62) 3521.1597.

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Published

2019-07-26

How to Cite

TOLEDO, D. C.; FALEIRO, M. B. R.; FERREIRA, H. H.; FARIA, A. M.; MATOS, M. P. C.; AMORIM, R. L.; DE MOURA, V. M. B. D. IMMUNOEXPRESSION OF TGF-? IN NORMAL CANINE PROSTATES AND WITH PROLIFERATIVE LESIONS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 20, p. 1–10, 2019. Disponível em: https://revistas.ufg.br/vet/article/view/34543. Acesso em: 16 aug. 2024.

Issue

Vol. 20 (2019): Continuous publication

Section

MEDICINA VETERINÁRIA

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