HAEMATOLOGY CHANGES DURING THE IMMUNIZATION AND AFTER THE BLEEDING AND PHASMAFERESE IN HORSES USED FOR HYPERIMUNE ANTI-CROTALIC SERUM PRODUCTION

Authors

  • Andrea Cristina Parra Universidade de São Paulo (USP), São Paulo, São Paulo, Brasil
  • Juarez Pinto Fernandes Távora
  • Ronaldo Azevedo Ferreira
  • Patrícia Stocco Betiol
  • Eduardo Harry Birgel

Keywords:

Horse clinical

Abstract

Twenty animals were used to assess the blood profile of horses during immunization for anticrotalic hyperimmune serum production and after the bleedings and the plasmapherese, according to the protocol schedule of Instituto Butantan in order to evaluate efficacy of plasmapheresis. The samples were obtained before the antigen inoculations (crotalic venon), before and after the bleedings, right after the plasmapherese and 15, 30 and 45 days after the last one, making a total of 340 collections in 17 moments. Samples were submitted to hemogram. Significant variations were observed on the blood profile of the horses throughout the immunization, showing normocytic, normochromic anemia, without significant alterations on leukogram. During the bleedings phases, evident variations were observed on the blood profile showing normocytic normochromic anemia after bleeding without changing the leukogram values. During rest periods, the efficacy of plasmapheresis was evident with a rapid, partial recovery of hemogram, making easier the fast return to hematologic normality, making them capable to a new hyperimmune serum production.KEY WORDS: Anticrotalic, equine, hematology, immunization, plasmapherese.

Downloads

Download data is not yet available.

Downloads

Published

2009-12-19

How to Cite

PARRA, Andrea Cristina; TÁVORA, Juarez Pinto Fernandes; FERREIRA, Ronaldo Azevedo; BETIOL, Patrícia Stocco; BIRGEL, Eduardo Harry. HAEMATOLOGY CHANGES DURING THE IMMUNIZATION AND AFTER THE BLEEDING AND PHASMAFERESE IN HORSES USED FOR HYPERIMUNE ANTI-CROTALIC SERUM PRODUCTION. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 10, n. 4, p. 1225–1230, 2009. Disponível em: https://revistas.ufg.br/vet/article/view/3264. Acesso em: 5 dec. 2025.

Issue

Vol. 10 No. 4 (2009)

Section

Veterinary Medicine

License

Copyright (c) 2009 Brazilian Animal Science/ Ciência Animal Brasileira

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).