Leucograma e metabolismo oxidativo dos neutrófilos de cães com leishmaniose visceral antes e após o tratamento com antimoniato de meglumina e alopurinol

Paulo César Ciarlini; Taiana Carvalho Valadares; Fabiana Augusta Ikeda-Garcia; Mary Marcondes; Valéria Marçal Félix de Lima

doi:10.5216/cab.v11i2.2149

LEUKOGRAM AND NEUTROPHIL OXIDATIVE METABOLISM OF DOGS WITH VISCERAL LEISHMANIASIS BEFORE AND AFTER TREATMENT WITH MEGLUMINE ANTIMONIATE AND ALLOPURINOL

Authors

Paulo César Ciarlini Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
Taiana Carvalho Valadares Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
Fabiana Augusta Ikeda-Garcia Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
Mary Marcondes Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
Valéria Marçal Félix de Lima Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil

DOI:

https://doi.org/10.5216/cab.v11i2.2149

Keywords:

Animal Sanity

Abstract

Leukogram and neutrophil oxidative metabolism from dogs with visceral leishmaniasis (VL) were compared before and after treatment with meglumine antimoniate (AM) and with an association of meglumine antimoniate and allopurinol (AMA). The results obtained demonstrated that neutrophils of dogs with VL do not lose their capacity of reducing NBT and that oxidative metabolism has been more active in the majority of the cases. After treatment with AM and AMA, dogs with VL presented a redution of neutrophils oxidative metabolism, suggesting that this decrease was related with the decrease in the number of parasites and a probable inhibitor effect of these drugs on neutrophils oxidative metabolism.

KEYWORDS: Glucantime, Leishmania sp, nitroblue tetrazolium (NBT), neutrophil functions.

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Published

2010-06-23

How to Cite

CIARLINI, Paulo César; VALADARES, Taiana Carvalho; IKEDA-GARCIA, Fabiana Augusta; MARCONDES, Mary; LIMA, Valéria Marçal Félix de. LEUKOGRAM AND NEUTROPHIL OXIDATIVE METABOLISM OF DOGS WITH VISCERAL LEISHMANIASIS BEFORE AND AFTER TREATMENT WITH MEGLUMINE ANTIMONIATE AND ALLOPURINOL. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 11, n. 2, p. 369–375, 2010. DOI: 10.5216/cab.v11i2.2149. Disponível em: https://revistas.ufg.br/vet/article/view/2149. Acesso em: 5 dec. 2025.

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Issue

Vol. 11 No. 2 (2010)

Section

Veterinary Medicine

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