LEUKOGRAM AND NEUTROPHIL OXIDATIVE METABOLISM OF DOGS WITH VISCERAL LEISHMANIASIS BEFORE AND AFTER TREATMENT WITH MEGLUMINE ANTIMONIATE AND ALLOPURINOL

Authors

  • Paulo César Ciarlini UNESP
  • Taiana Carvalho Valadares UNESP
  • Fabiana Augusta Ikeda-Garcia UNESP
  • Mary Marcondes UNESP
  • Valéria Marçal Félix de Lima UNESP

DOI:

https://doi.org/10.5216/cab.v11i2.2149

Keywords:

Animal Sanity

Abstract

Leukogram and neutrophil oxidative metabolism from dogs with visceral leishmaniasis (VL) were compared before and after treatment with meglumine antimoniate (AM) and with an association of meglumine antimoniate and allopurinol (AMA). The results obtained demonstrated that neutrophils of dogs with VL do not lose their capacity of reducing NBT and that oxidative metabolism has been more active in the majority of the cases. After treatment with AM and AMA, dogs with VL presented a redution of neutrophils oxidative metabolism, suggesting that this decrease was related with the decrease in the number of parasites and a probable inhibitor effect of these drugs on neutrophils oxidative metabolism. 

KEYWORDS: Glucantime, Leishmania sp, nitroblue tetrazolium (NBT), neutrophil functions.

Downloads

Download data is not yet available.

Author Biographies

Paulo César Ciarlini, UNESP

Professo Assistente Doutor, Departamento de Clínica, Cirurgia e Reprodução Animal. Responsável pelas disciplinas de Laboratório Clínico Veterinário e Metodologia Científica.

Taiana Carvalho Valadares, UNESP

Graduanda Medicina Veterinária, Bolsista Iniciação Científica da FAPESP.

Fabiana Augusta Ikeda-Garcia, UNESP

Professora Voluntária, Departamento de Clínica, Cirurgia e Reprodução Animal. Disciplina de Clínica Médica de Pequenos Animais.

Mary Marcondes, UNESP

Professora Assitente Doutora, Departamento de Clínica, Cirurgia e Reprodução Animal. Responsável pela Disciplinja de Clínica Médica de Pequenos Animais.

Valéria Marçal Félix de Lima, UNESP

Professora Assistente Doutora, Departamento de Clínica, Cirurgia e reprodução Animal, Responsável pela Disciplina de Imunologia Veterinária.

Downloads

Published

2010-06-23

How to Cite

CIARLINI, P. C.; VALADARES, T. C.; IKEDA-GARCIA, F. A.; MARCONDES, M.; DE LIMA, V. M. F. LEUKOGRAM AND NEUTROPHIL OXIDATIVE METABOLISM OF DOGS WITH VISCERAL LEISHMANIASIS BEFORE AND AFTER TREATMENT WITH MEGLUMINE ANTIMONIATE AND ALLOPURINOL. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 11, n. 2, p. 369–375, 2010. DOI: 10.5216/cab.v11i2.2149. Disponível em: https://revistas.ufg.br/vet/article/view/2149. Acesso em: 27 jul. 2024.

Issue

Vol. 11 No. 2 (2010)

Section

Veterinary Medicine

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).