uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS

Authors

  • Mariana Rodrigues Faleiro UFG- Universidade Federal de Goiás
  • Denise Caroline Toledo Universidade Federal de Goiás
  • Marcela M. Pinto Rodrigues Universidade estadual Paulista Julio de Mesquita Filho campus-Botucatu-sp
  • Renee Laufer Amorim Universidade estadual Paulista Julio de Mesquita Filho campus-Botucatu-sp
  • Luiz Augusto B. Brito Universidade Federal de Goiás
  • Adilson Donizeti Damasceno Universidade Federal de Goiás
  • Veridiana M. B. Dignani de Moura Universidade Federal de Goiás

DOI:

https://doi.org/10.5216/cab.v14i2.18930

Keywords:

Animal Sanity

Abstract

Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

KEYWORDS: CD87; PIA; PIN; prostatic carcinoma; TMA.

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Author Biographies

Mariana Rodrigues Faleiro, UFG- Universidade Federal de Goiás

Veterinary Pathology Services, Department of Veterinary Medicine

Denise Caroline Toledo, Universidade Federal de Goiás

Veterinary Pathology Services, Department of Veterinary Medicine

Marcela M. Pinto Rodrigues, Universidade estadual Paulista Julio de Mesquita Filho campus-Botucatu-sp

Veterinary Pathology Services, Department of Clinical, School of Veterinary Medicine and Animal Science

Renee Laufer Amorim, Universidade estadual Paulista Julio de Mesquita Filho campus-Botucatu-sp

Veterinary Pathology Services, Department of Clinical, School of Veterinary Medicine and Animal Science

Luiz Augusto B. Brito, Universidade Federal de Goiás

Veterinary Pathology Services, Department of Veterinary Medicine

Adilson Donizeti Damasceno, Universidade Federal de Goiás

Veterinary Pathology Services, Department of Veterinary Medicine

Veridiana M. B. Dignani de Moura, Universidade Federal de Goiás

Veterinary Pathology Services, Department of Veterinary Medicine

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Published

2013-06-27

How to Cite

FALEIRO, M. R.; TOLEDO, D. C.; RODRIGUES, M. M. P.; AMORIM, R. L.; BRITO, L. A. B.; DAMASCENO, A. D.; MOURA, V. M. B. D. de. uPAR EXPRESSION IN CANINE NORMAL PROSTATE AND WITH PROLIFERATIVE DISORDERS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 14, n. 2, p. 237–244, 2013. DOI: 10.5216/cab.v14i2.18930. Disponível em: https://revistas.ufg.br/vet/article/view/18930. Acesso em: 17 jul. 2024.

Issue

Vol. 14 No. 2 (2013)

Section

Veterinary Medicine

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