SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS

Authors

  • Sérgio Diniz Garcia Universidade Estadual Paulista (UNESP), Araçatuba, São Paulo, Brasil
  • Silvia Helena Venturoli Perri Universidade Estadual Paulista (UNESP), Araçatuba, São Paulo, Brasil
  • Gilberto Chierice Universidade de São Paulo(USP), São Carlos, São Paulo, Brasil
  • Daniel Cardoso Agência Paulista de Tecnologia do Agronegócio

Keywords:

Toxicologia

Abstract

Castor oil polymer is a biomaterial that can be used to fill bone defects. Biomaterials should present some characteristics such as: biocompatibility, inert, absence of toxin radical and vapour discharge and permit the organism to recognize them as a part of their structure. The aim of this study was to investigate changes in water ingestion, feed intake, weight gain and toxic effects in rats (Rattus norvegicus) after ingestion of 0, 10, 25 and 50% of castor oil polymer (COP, Ricinus communis). In groups that received 10 and 25% of COP the weight gain was smaller than the control group. Feed intake in control group was greater than in groups 10 and 50% COP. The intake of castor oil polymer reduced feed intake and water ingest probably because of the palatability of the product. In the second part of this study (multigenerational) there were no toxic effects in the offspring, as external birth defects or alterations incompatible with life, in spite of the fact that lower weight were observed in males and females of the second generation.

KEY WORDS: Biomaterials, bone defects, polymer, Ricinus communis.

Downloads

Download data is not yet available.

Author Biography

Daniel Cardoso, Agência Paulista de Tecnologia do Agronegócio

 

 

Downloads

Published

2009-04-03

How to Cite

GARCIA, Sérgio Diniz; PERRI, Silvia Helena Venturoli; CHIERICE, Gilberto; CARDOSO, Daniel. SUBACUTE AND MULTIGENERATIONAL TOXICITY EVALUATION OF CASTOR OIL POLYMER INGESTION IN RATS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 10, n. 1, p. 219–225, 2009. Disponível em: https://revistas.ufg.br/vet/article/view/1660. Acesso em: 5 dec. 2025.

Issue

Vol. 10 No. 1 (2009)

Section

Veterinary Medicine

License

Copyright (c) 2009 Brazilian Animal Science/ Ciência Animal Brasileira

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).