CYTOPATHOLOGICAL ASPECTS OF FEMALE MICES VAGINAL MUCOSA TREATEDS WITH MEDROXYPROGESTERONE

Abstract

The domestic mammal’s estrus cycle regulation is a complex process, controlled by hypothalamus-adenohy¬pofisis-ovary axis, through endocrine and neuroendocrine mechanisms. The use of progesterone hormone is an im¬portant way to regulate the functional and structural female reproductive tract activity. Considering the frequent pro¬gesterone usage and its importance, we intended to study the vagina citopathologycal aspects of female mice treated with progesterone. We used thirty six Swiss Webster female mice. These animals were divided in four groups: S Group (control group- female mice treated with vehicle and valued during fifteen days), Groups E1, E2 e E3 (Experimental groups - female mice treated with 0,375 mg, 0,75 mg and 1,5 mg of medroxiprogesterone acetate and valued during fifteen days). Based on our results, we can conclude that medroxiproges¬terone acetate at once dose at 0,75 mg or 1,5 mg induces to estrus cycle interruption an induces to an increasing number of leucocytes observed at vaginal cytological exam. KEY-WORDS: Colpocytology, estral cycle, interruption of estrus cycle, medroxiprogesterone.