EFFECT OF DRY COW THERAPY DRUGS ON PHAGOCYTOSIS RATES

Authors

  • Camila Freitas Batista FMVZ-USP
  • Maiara Garcia Blagitz FMVZ-USP
  • Milton Ricardo Azedo FMVZ-USP
  • Cláudia Regina Stricagnolo FMVZ-USP
  • Alice Maria Melville Paiva Della Libera FMVZ-USP

DOI:

https://doi.org/10.5216/cab.v10i2.1212

Keywords:

Tratamento, período seco, mastite, imunologia

Abstract

The dry period is considered to be a phase when cows are very vulnerable to mastitis and phagocytosis mechanisms are specially important at this moment. The objective of the present trial was to evaluate the influence of dry cow therapy drugs available in the market on the phagocytic function of leukocytes obtained from cow milk. In order to do that, paired milk samples negative in bacteriological examination were submitted to in vitro phagocytosis test, after they were exposed to solutions of the following drugs: anhydrous cephalonium (M1), Gentamicin (M2), Benzylpenicillin procaine associated with Nafcillin and Dihydrostreptomycin (M3) and Cloxacillin benzathine (M4). Mean phagocytosis rates of control samples and of cells submitted to treatments M1 and M3 were, respectively, (58.88% ± 12.04), (64.87% ± 15.36) and (65.14% ± 17.96) there were no differences among these samples, as well as in the comparison with the control group. Mean phagocytosis rate obtained in cells submitted to treatment M4 (46.90% ± 22.08) was lower than that of the control group, and than that of cells submitted to treatments M1 and M3. On the other hand, mean phagocytosis rate of cells submitted to treatment M2 (0.68% ± 1.63) was lower than that observed in the control group, and than that of all other treatments. These results show that the use of drugs available for dry cow therapy may no be totally innocuous for the host.

KEY WORDS: Dry period, mastitis, phagocytosis, treatment.

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Author Biographies

Camila Freitas Batista, FMVZ-USP

Departamento de Clínica Médica Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

Maiara Garcia Blagitz, FMVZ-USP

Departamento de Clínica Médica Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

Milton Ricardo Azedo, FMVZ-USP

Departamento de Clínica Médica Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

Cláudia Regina Stricagnolo, FMVZ-USP

Departamento de Clínica Médica Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

Alice Maria Melville Paiva Della Libera, FMVZ-USP

Departamento de Clínica Médica Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo

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Published

2009-07-03

How to Cite

BATISTA, C. F.; BLAGITZ, M. G.; AZEDO, M. R.; STRICAGNOLO, C. R.; DELLA LIBERA, A. M. M. P. EFFECT OF DRY COW THERAPY DRUGS ON PHAGOCYTOSIS RATES. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 10, n. 2, p. 574–580, 2009. DOI: 10.5216/cab.v10i2.1212. Disponível em: https://revistas.ufg.br/vet/article/view/1212. Acesso em: 22 nov. 2024.

Issue

Vol. 10 No. 2 (2009)

Section

Veterinary Medicine

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