THE ROLE OF Nicotiana glauca GRAHAM (PARAGUAYAN HERBS) AS AN ADJUVANT IN IMMUNOMODULATION OF NEWCASTLE DISEASE VACCINE FOR BROILERS

Authors

  • Marlete Brum Cleff UFPel
  • Geferson Fischer DSc., Professor Nível E, Conjunto Agrotécnico Visconde da Graça, Universidade Federal de Pelotas
  • Caren Gularte Quincozes DSc., Professor Nível E, Conjunto Agrotécnico Visconde da Graça, Universidade Federal de Pelotas
  • Marcos Antônio Anciuti DSc., Professor Nível E, Conjunto Agrotécnico Visconde da Graça, Universidade Federal de Pelotas
  • Rogério Freitag DSc., Professor Nível E, Conjunto Agrotécnico Visconde da Graça, Universidade Federal de Pelotas
  • Telmo Vidor DSc., Professor Nível E, Conjunto Agrotécnico Visconde da Graça, Universidade Federal de Pelotas
  • Fabiane Pereira Gentilini DSc., Grupo de Estudos em Aves e Suínos (GEASPEL), do Departamento de Zootecnia, da Universidade Federal de Pelotas/RS
  • Carlos Eduardo Nogueira DSc., Grupo de Estudos em Aves e Suínos (GEASPEL), do Departamento de Zootecnia, da Universidade Federal de Pelotas/RS

DOI:

https://doi.org/10.5216/cab.v9i2.1086

Abstract

The Nicotiana glauca is a native plant species from Argentina, but found all over South América, being used against headaches, rheumatism, injuries, ulcers, and so on. Researchers have considered it as having immunomodulation effect. This study was conducted to investigate the use of a aqueous extract of Nicotiana glauca Graham as an immunomodulator (adjuvant) of a Newcastle disease vaccine.. A total of 56 broilers were distributed into 4 experimental groups. Each one of them received 3 dosages of this vaccine with or without the addition of different concentrations of the extract Using hemmoaglutination inhibition techniques , the results have shown differences (P<0.05) in the third sera collection. An increase in the antibody titer with the inclusion of 5 mg/dosage of the extract (Treatment 3) as compared to 1 mg/dosage (Treatment 2) and 10 mg/dosage of the extract (Treatment 4) was observed, However, birds from Treatment 3 did not differ (P> 0.05) from Treatment 1. These results indicated that further investigations are required, including the use of cytotoxicity tests in vitro, to evaluate the immunomodulation effect of this extract.

 

KEY WORDS: Immunomodulation effect, Nicotiana glauca Graham, vaccine.

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Author Biographies

Marlete Brum Cleff, UFPel

Doutoranda, Departamento de Veterinária Preventiva, Universidade Federal de Pelotas

Marcos Antônio Anciuti, DSc., Professor Nível E, Conjunto Agrotécnico Visconde da Graça, Universidade Federal de Pelotas

DSc., Professor Nível E Conjunto Agrotécnico Visconde da Graça, Universidade Federal de Pelotas

Fabiane Pereira Gentilini, DSc., Grupo de Estudos em Aves e Suínos (GEASPEL), do Departamento de Zootecnia, da Universidade Federal de Pelotas/RS

DSc., Grupo de Estudos em Aves e Suínos (GEASPEL), do Departamento de Zootecnia, da Universidade Federal de Pelotas/RS

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Published

2008-07-09

How to Cite

CLEFF, M. B.; FISCHER, G.; QUINCOZES, C. G.; ANCIUTI, M. A.; FREITAG, R.; VIDOR, T.; GENTILINI, F. P.; NOGUEIRA, C. E. THE ROLE OF Nicotiana glauca GRAHAM (PARAGUAYAN HERBS) AS AN ADJUVANT IN IMMUNOMODULATION OF NEWCASTLE DISEASE VACCINE FOR BROILERS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 9, n. 2, p. 375–382, 2008. DOI: 10.5216/cab.v9i2.1086. Disponível em: https://revistas.ufg.br/vet/article/view/1086. Acesso em: 17 jul. 2024.

Issue

Vol. 9 No. 2 (2008)

Section

Veterinary Medicine

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