Atividade da lactato desidrogenase (LDH) sérica em cães submetidos à oxigenação extracorpórea por membrana (ECMO) por um período de três horas

Felipp Silveira Ferreira; Lara Lages Silveira; Alessandra Castello Costa; Daniela Fantini Vale; Claudio Baptista Carvalho; Josias Alves Machado; André L. de Abreu Oliveira

doi:10.5216/cab.v12i3.10148

SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS

Authors

Felipp Silveira Ferreira Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil
Lara Lages Silveira Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil
Alessandra Castello Costa Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil
Daniela Fantini Vale Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil
Claudio Baptista Carvalho Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil
Josias Alves Machado Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil
André L. de Abreu Oliveira Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil

DOI:

https://doi.org/10.5216/cab.v12i3.10148

Keywords:

Animal sanity

Abstract

The extracorporeal membrane oxygenation (ECMO) is a prolonged cardiopulmonary support technique, which aims to help the lungs and the heart when they do not respond to conventional non-invasive treatments. This research was carried out to determine the behavior of lactate dehydrogenase (LDH) of five mongrel dogs undergoing ECMO for three hours. Under controlled ventilation, positive end-expiratory pressure (PEEP) at 10mmHg and FiO2 at 21%, the animals were submitted to femoral cannulation for ECMO (artery and vein), by the arterial-venous (AV) deviation. The LDH was measured and evaluated every thirty minutes for an uninterrupted period of three hours. The results were tabulated and statistically analyzed with ANOVA and Tukey tests, with p<0.05. The results showed an increase of serum LDH, featuring a muscle injury during the procedure due to a physiological response, similar to that caused by a hypovolemic shock. We concluded that ECMO is a viable technique for prolonged ventilatory support, but it needs some adjustments for clinical use in dogs.
KEYWORDS: dogs: ECMO; lactate dehydrogenase.

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Published

2011-09-29

How to Cite

FERREIRA, Felipp Silveira; SILVEIRA, Lara Lages; COSTA, Alessandra Castello; VALE, Daniela Fantini; CARVALHO, Claudio Baptista; MACHADO, Josias Alves; OLIVEIRA, André L. de Abreu. SERUM LACTATE DEHYDROGENASE (LDH) ACTIVITY IN DOGS SUBMITTED TO EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) FOR THREE HOURS. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 12, n. 3, p. 554–559, 2011. DOI: 10.5216/cab.v12i3.10148. Disponível em: https://revistas.ufg.br/vet/article/view/10148. Acesso em: 5 dec. 2025.

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Issue

Vol. 12 No. 3 (2011)

Section

Veterinary Medicine

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