Chronic kidney disease following poisoning by ethylene glycol in a dog: a case report
Abstract
A seven-year-old, 4.65 kg, male Shih-tzu dog was referred to the veterinary hospital with a history of vomiting after eating a commercial dog treat containing ethylene glycol (EG) in its formulation. The animal showed clinical signs of kidney damage and after additional tests was diagnosed with severe grade 4 acute kidney injury. Almost one and half years later, the patient was presented to veterinary care, with a grade 4, chronic kidney injury. During this period, several tests were carried out, including a complete blood count, serum biochemistry analysis, abdominal ultrasound, and blood gas analysis. In critical condition, the animal died shortly afterward. An anatomopathological necropsy exam revealed extensive kidney injury with tubular necrosis and glomerular sclerosis, fibrosis, and mineralization, accompanied by numerous mono and dihydrates oxalate crystals. To our knowledge, this is the first report describing clinical signs and pathological findings of a dog poisoned by EG in Brazil. We aim to contribute to the understanding of the pathogenesis of EG poisoning, especially regarding chronic kidney failure.
Keywords: Canine; forensic toxicology; intoxication; kidney injury; toxicologic pathology
Keywords: Canine; forensic toxicology; intoxication; kidney injury; toxicologic pathology.
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