Effects of 48-hour feed deprivation on acute-phase response in horses

Paula Alessandra Di Filippo; Bárbara Ribeiro Duarte; Antônio Peixoto Albernaz; Leandro Abreu da Fonseca; Inácio Silva Viana; Célia Raquel Quirino

doi:10.1590/1809-6891v23e-72445E

Autores

Paula Alessandra Di Filippo Universidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil https://orcid.org/0000-0001-9601-4471
Bárbara Ribeiro Duarte Universidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil https://orcid.org/0000-0002-2898-2603
Antônio Peixoto Albernaz Universidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil https://orcid.org/0000-0003-2242-8502
Leandro Abreu da Fonseca Universidade Federal de Viçosa (UFV), Viçosa, Minas Gerais, Brasil https://orcid.org/0000-0001-5296-6657
Inácio Silva Viana Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Jaboticabal, São Paulo, Brasil https://orcid.org/0000-0003-3678-0611
Célia Raquel Quirino Universidade Estadual do Norte Fluminense "Darcy Ribeiro" (UENF), Campos dos Goytacazes, Rio de Janeiro, Brasil https://orcid.org/0000-0001-6039-1259

DOI:

https://doi.org/10.1590/1809-6891v23e-72445E

Resumo

O objetivo deste estudo foi avaliar o efeito da restrição alimentar na resposta de fase aguda em equinos. Vinte cavalos foram submetidos à restrição alimentar por 48 h enquanto outros 12 animais (controle) tiveram livre acesso à água e alimento. Os animais foram monitorados, examinados e amostras de sangue foram coletadas no início (0) do estudo e com 6, 12, 18, 24, 30, 36, 42 e 48 horas de restrição alimentar. Os dados foram submetidos à análise de variância bidirecional com medidas repetidas e a significância estatística foi P ≤ 0,05. Os cavalos toleraram a restrição alimentar sem complicações clínicas relevantes. A restrição alimentar induziu uma resposta de fase aguda caracterizada pela elevação das concentrações séricas de α2-macroglobulina (24-38 h), ceruloplasmina (36-48 h), α1-antitripsina (30-48 h), α1-glicoproteína ácida (42-48 h) e haptoglobina (42-48 h). A privação de nutrientes eleva os níveis de cortisol circulante, que atua no sistema imunológico inato o qual, então induz a resposta de fase aguda. Em conclusão, a restrição alimentar é um fator estressor físico para equinos, capaz de induzir uma reação proteica de fase aguda, caracterizada pelo aumento na produção de α2-macroglobulina, ceruloplasmina, α1-antitripsina, α1-glicoproteína ácida e haptoglobina.
Palavras-chave: Equinos; Restrição alimentar; Inflamação; Resposta imune; Proteína; Estresse.

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