O papel da ciclooxigenase-2 e da pressão arterial na lesão renal de ratos submetidos à infusão contínua de angiotensina II

Flávia Santin; Maria do Carmo Fernandez Vailati; Marcela Marcondes Pinto Rodrigues; David Michelucci; Luis Cuadrado Martin; Denise Saretta Schwartz

doi:10.5216/cab.v11i4.4635

THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II

Authors

Flávia Santin Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
Maria do Carmo Fernandez Vailati Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
Marcela Marcondes Pinto Rodrigues Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
David Michelucci Universidade do Estado de Santa Catarina (UDESC), Florianópolis, Santa Catarina, Brasil
Luis Cuadrado Martin Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil
Denise Saretta Schwartz Universidade de São Paulo(USP), São Paulo, São Paulo, Brasil

DOI:

https://doi.org/10.5216/cab.v11i4.4635

Keywords:

Animal Sanity

Abstract

Angiotensin II (ANGII) is a vasoconstrictor which action on inflammation has been studied. The objective of this study was to verify the stimulation of cyclooxigenase-2 and blood pressure on renal damage by ANGII. Wistar rats were distributed into four groups, as follows: group 1 – control; group 2 – ANGII; group 3 – ANGII + celecoxib; and group 4 – celecoxib. The ANGII was infused in the animals by subcutaneous osmotic mini-pumps during 72 hours. After that, euthanasia was performed. The blood pressure was measured before the drugs administration and before the euthanasia. Histopathological and immunohistochemical evaluations were performed in kidneys to assess the expression of COX-2. It was concluded that ANGII caused renal damage, regardless of blood pressure values. ANGII associated with celeboxib increased blood pressure. Celecoxib did not protect the kidneys against ANGII activities.

KEYWORDS: Blood pressure, celecoxib, nephrotoxicity.

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Published

2010-12-21

How to Cite

SANTIN, Flávia; VAILATI, Maria do Carmo Fernandez; RODRIGUES, Marcela Marcondes Pinto; MICHELUCCI, David; MARTIN, Luis Cuadrado; SCHWARTZ, Denise Saretta. THE ROLE OF CYCLOOXIGENASE-2 AND BLOOD PRESSURE ON THE KIDNEY DAMAGE IN RATS SUBMITTED TO CONTINUOUS INFUSION OF ANGIOTENSIN II. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 11, n. 4, p. 867–873, 2010. DOI: 10.5216/cab.v11i4.4635. Disponível em: https://revistas.ufg.br/vet/article/view/4635. Acesso em: 21 dec. 2025.

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Issue

Vol. 11 No. 4 (2010)

Section

Veterinary Medicine

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