Imunoexpressão de maspin e ki-67 como marcadores prognósticos da caracterização benigna da hiperplasia fibroepitelial mamária canina

Debora Aparecida P. de Campos Zuccari; Rodrigo Castro; Cibelli Soares Frade; Luana Roberta Pivaro; Juliana Carmona-Raphe; Zilda Mayer

doi:10.5216/cab.v11i4.3773

IMMUNOEXPRESSION OF MASPIN AND KI-67 AS PROGNOSTIC MARKERS FOR BENIGN CHARACTERIZATION OF A CANINE MAMMARY FIBROEPITHELIAL HYPERPLASIA: CASE REPORT

Authors

Debora Aparecida P. de Campos Zuccari Faculdade de medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brasil
Rodrigo Castro Faculdade de medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brasil
Cibelli Soares Frade Faculdade de medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brasil
Luana Roberta Pivaro Faculdade de medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brasil
Juliana Carmona-Raphe Faculdade de medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brasil
Zilda Mayer Faculdade de medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, São Paulo, Brasil

DOI:

https://doi.org/10.5216/cab.v11i4.3773

Keywords:

Animal Sanity

Abstract

Mammary hyperplasia is characterized by an increase in the whole mammary gland, considered benign and with a good prognosis. A two-year-old dog showed a volume increase in the entire mammary chain after hormone stimulation. To characterize the process prognosis, a immunohistochemical procedure was used to evaluate the Maspin staining, considered good prognosis marker, and the Ki-67, a proliferation marker, whose high expression indicates malignancy. As a result, we obtained a low expression of Ki-67 and a high expression of Maspin, suggesting an excellent prognosis for the animal.

Keywords: Female dog, imunohistochemistry, neoplasia, prognosis.

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Published

2010-12-21

How to Cite

ZUCCARI, Debora Aparecida P. de Campos; CASTRO, Rodrigo; FRADE, Cibelli Soares; PIVARO, Luana Roberta; CARMONA-RAPHE, Juliana; MAYER, Zilda. IMMUNOEXPRESSION OF MASPIN AND KI-67 AS PROGNOSTIC MARKERS FOR BENIGN CHARACTERIZATION OF A CANINE MAMMARY FIBROEPITHELIAL HYPERPLASIA: CASE REPORT. Brazilian Animal Science/ Ciência Animal Brasileira, Goiânia, v. 11, n. 4, p. 977–980, 2010. DOI: 10.5216/cab.v11i4.3773. Disponível em: https://revistas.ufg.br/vet/article/view/3773. Acesso em: 21 dec. 2025.

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Issue

Vol. 11 No. 4 (2010)

Section

Case report

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