Associação entre polimorfismos de genes do eixo somatotrópico e eficiência reprodutiva de fêmeas bovinas: revisão de literatura
DOI:
https://doi.org/10.1590/1809-6891v23e-72386EResumo
Características reprodutivas refletem diretamente no desempenho produtivo visto que são capazes de determinar o número de bezerros nascidos anualmente, além de afetar o intervalo entre gerações e, consequentemente, a intensidade de seleção, fazendo com o que tais atributos sejam apontados como variáveis econômicas das mais importantes que afetam diretamente o sistema de produção. O presente estudo propõe realizar uma revisão de literatura de polimorfismos de genes do eixo somatotrópico associados a funções reprodutivas em novilhas e vacas (Bos taurus taurus e Bos taurus indicus), indicadas pelos índices: número de serviços por gestação (Nº serviços/gestação), idade ao primeiro parto (IPP), intervalo de partos (IP) e período de serviço, como também denominado de intervalo parto-concepção (IPC). As pesquisas encontradas durante o período de 2011 a 2021 demonstraram associações entre todos os indicadores de eficiência reprodutiva analisados de novilhas e vacas com 27 polimorfismos de nucleotídeo único (SNPs), sendo 18 em GHR, 5 em IGF-I e 4 em STAT5A. Dessa forma, este estudo mostrou relação entre os SNPs e os indicadores de eficiência reprodutiva, demonstrando que técnicas de genética molecular potencializam o processo de seleção dos animais, resultando em sistemas mais lucrativos e que se sustentam a longo prazo.
Palavras-chave: Genética molecular; IGF-I; Reprodução animal; SNPs; STAT5A.
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Referências
Buzanskas ME, Pires PS, Chud TCS, Bernardes PA, Rola LD, Savegnago RP, Lôbo RB, Munari DP. Parameter estimates for reproductive and carcass traits in Nelore beef cattle. Theriogenology. 2017;92:204-209. Available from: https://pubmed.ncbi.nlm.nih.gov/28237337/
Lacerda VV, Campos GS, Roso VM, Souza FRP, Brauner CC, Boligon AA. Effect of mature size and body condition of Nelore females on the reproductive performance. Theriogenology. 2018;118:27-33. Doi:10.1016/j.theriogenology.2018.05.036
Grossi DA, Venturini GC, Paz CC, et al. Genetic associations between age at first calving and heifer body weight and scrotal circumference in Nelore cattle. J Anim Breed Genet. 2009;126(5):387-393. Doi:10.1111/j.1439-0388.2008.00791.x
Falconer DS. Introduction to quantitative genetics, 3th ed. Longman Scientific & Technical; 1989. 448p. English. Available from: (https://vulms.vu.edu.pk/Courses/GEN733/Downloads/Introduction%20to%20Quantitative%20Genetic-DS%20Falconer.pdf )
Polido PB, Ferreira GF, Alberton O, De Souza SGH. Marcadores moleculares aplicados no melhoramento genético de bovinos. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR. 2012;15(2):161-169. Available from: https://revistas.unipar.br/index.php/veterinaria/article/view/4221
Silva AA. Valor genético estimado e QTL afetando porcentagem de sólidos totais na raça bovina gir. Revista de Medicina Veterinaria. 2010;20:27-37. Available from: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0122-93542010000200003
Montaldo Hugo H., Meza-Herrera Cesar A.. Use of molecular markers and major genes in the genetic improvement of livestock. Electron. J. Biotechnol. [Internet]. 1998 Ago [citado 2022 Mar 12] ; 1( 2 ): 15-16. Available from: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34581998000200004&lng=es. http://dx.doi.org/10.4067/S0717-34581998000200004.
Menezes IPP, Gaiotto F, Suassuna N, Hoffmann L, Barroso P. Susceptibility of Gossypium mustelinum Populations to the Main Cotton Diseases in Brazil. Journal of Agricultural Science. 2014;6(3):39-47. Available from: https://ccsenet.org/journal/index.php/jas/article/view/32693
Eler JP, Bignardi AB, Ferraz JB, Santana MLJ. Genetic relationships among traits related to reproduction and growth of Nelore females. Theriogenology. 2014;82(5):708-714. Available from: https://pubmed.ncbi.nlm.nih.gov/25023297/
Paiva JT, Resende MDV, Resende RT, Oliveira HR, Silva HT, et al. Herdabilidade de características de crescimento em bovinos da raça Nelore utilizando métodos da Máxima Verossimilhança Restrita e Inferência Bayesiana. Archivos de Zootecnia. 2019;68(263):440–446. Available from: https://www.researchgate.net/publication/335562867_Herdabilidade_de_caracteristicas_de_crescimento_em_bovinos_da_raca_Nelore_utilizando_metodos_da_Maxima_Verossimilhanca_Restrita_e_Inferencia_Bayesiana
ABCZ, Associação brasileira de criadores de zebu. Avaliação Genética. Versão 3.2.8.18. PMGZ Corte: Programa de Melhoramento Genético Zebuíno, 2022-1. (https://www.abczstat.com.br/comunicacoes/sumario/default.aspx?acesso=publico).
Meuwissen TH, Hayes BJ, Goddard ME. Prediction of total genetic value using genome-wide dense marker maps. Genetics. 2001;157(4):1819-1829. Available from: https://pubmed.ncbi.nlm.nih.gov/11290733/
Zhang T, Guo L, Shi M, et al. Selection and effectiveness of informative SNPs for paternity in Chinese Simmental cattle based on a high-density SNP array. Gene. 2018;673:211-216. Available from: https://pubmed.ncbi.nlm.nih.gov/29933017/
Sharifiyazdi H, Mirzaei A, Ghanaatian Z. Characterization of polymorphism in the FSH receptor gene and its impact on some reproductive indices in dairy cows. Animal Reproduction Science. 2018;188:45-50. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0378432017305304
Meyer L, Powell J, Kutz B, Looper M, Brown JAH, Rosenkrans JC. Associations of single nucleotide polymorphisms in the bovine prolactin gene with phenotypic traits in beef cattle. Agri Gene. 2017;5:7-11. Available from: https://www.sciencedirect.com/science/article/abs/pii/S2352215117300090?via%3Dihub
Barbero, MMD, Santos DJA, Takada L, De Camargo GMF, Freitas AC, Diaz, ISDP, De Souza FRP, Tonhati H, Albuquerque LG, Oliveira HN. Prospecting polymorphisms in the PPP3CA and FABP4 genes and their association with early pregnancy probability in Nellore heifers. Livestock Science. 2017;203:76-81. Available from: https://repositorio.unesp.br/handle/11449/174937
Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocrine Reviews. 1995;16(1):3-34. Available from: https://pubmed.ncbi.nlm.nih.gov/7758431/
Argetsinger LS, Campbell GS, Yang X, Witthuhn BA, Silvennoinen O, Ihle JN, Carter-Se C. Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase. Cell. 1993;74(2):237-244. Available from: https://www.cell.com/fulltext/0092-8674(93)90415-M
Armstrong DG, Webb R. Ovarian follicular dominance: the role of intraovarian growth factors and novel proteins. Reviews of Reproduction. 1997;2(3):139-146. Available from: https://pubmed.ncbi.nlm.nih.gov/9414477/
Rhoads ML, Meyer JP, Lamberson WR, Keisler DH, Lucy MC. Uterine and hepatic gene expression in relation to days postpartum, estrus, and pregnancy in postpartum dairy cows. Journal of Dairy Science. 2008;91(1):140-150. Available from: https://www.journalofdairyscience.org/article/S0022-0302(08)71447-4/fulltext
Butler WR. Energy balance relationships with follicular development, ovulation and fertility in postpartum dairy cows. Livestock Production Science. 2003;83:211-218. Available from: https://www.sciencedirect.com/science/article/abs/pii/S030162260300112X
Song N, Luo J, Huang L, Zang S, He Q, Wu J, Huang J. Mutation of Signal Transducer and Activator of Transcription 5 (STAT5) Binding Sites Decreases Milk Allergen αS1-Casein Content in Goat Mammary Epithelial Cells. Foods. 2022;11(3): 346. Available from: https://pubmed.ncbi.nlm.nih.gov/35159497/
Darwash AO, Lamming GE, Woolliams JA. Estimation of Genetic Variation in the Interval from Calving to Postpartum Ovulation of Dairy Cows. Journal of Dairy Science. 1997;80(6),1227-1234. Available from: https://pubmed.ncbi.nlm.nih.gov/9201595/
Schneider A, Corrêa MN, Butler WR. Association between growth hormone receptor AluI polymorphism and fertility of Holstein cows. Theriogenology. 2013;80(9):1061-1066. Available from: https://pubag.nal.usda.gov/catalog/612321
Hax LT, Schneider A, Jacometo CB, Mattei, Silva TC, Farina G, Corrêa MN. Association between polymorphisms in somatotropic axis genes and fertility of Holstein dairy cows. Theriogenology. 2017;88:67-72. Available from: https://pubag.nal.usda.gov/catalog/5252267
Leyva-Corona JC, Reyna-Granados JR, Zamorano-Algandar R, Sanchez-Castro MA, Thomas MG, EnnsRM, Speidel SE, Medrano JF, Rincon G, Luna-Nevarez P. Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate. Tropical Animal Health and Production. 2018;50, 1913–1920. Available from: https://link.springer.com/article/10.1007/s11250-018-1645-0#citeas
Waters SM, McCabe MS, Howard DJ, Giblin L, Magee DA, MacHugh DE, Berry DP. Associations between newly discovered polymorphisms in the Bos taurus growth hormone receptor gene and performance traits in Holstein-Friesian dairy cattle. Animal Genetics. 2011;42(1):39–49. Available from: https://pubmed.ncbi.nlm.nih.gov/20528848/
Fedota OM, Lysenko NG, Ruban SYu, Kolisnyk OI, Goraychuk IV. The effects of polymorphisms in growth hormone and growth hormone receptor genes on production and reproduction traits in Aberdeen-Angus cattle (Bos taurus L., 1758). Cytology and Genetics. 2017;51(5):352-360. Available from: https://link.springer.com/article/10.3103/S0095452717050024
Silva Silveira PA, Butler WR, da Silva TC, Barros CC, Corrêa MN, Schneider A. Association of polymorphisms in the IGF-I, GHR and STAT5A genes with serum IGF-I concentration and reproductive performance of Holstein dairy cows. Animal reproduction science. 2019;211:106206. Available from: https://pubmed.ncbi.nlm.nih.gov/31785637/
Abdolmohammadi A, Zamani P. SNP exploring in the middle and terminal regions of the IGF-1 gene and association with production and reproduction traits in Holstein cattle. Gene. 2014;25;540(1):92-5. Available from: https://pubmed.ncbi.nlm.nih.gov/24530703/
Nicolini P, Carriquiry M, Meikle A. A polymorphism in the insulin-like growth factor 1 gene is associated with postpartum resumption of ovarian cyclicity in Holstein-Friesian cows under grazing conditions. Acta Veterinaria Scandinavica. 2013;55(1):11. Published 2013 Feb 14. Available from: https://pubmed.ncbi.nlm.nih.gov/23409757/
Oikonomou G, Michailidis G, Kougioumtzis A, Avdi M, Banos G. Effect of polymorphisms at the STAT5A and FGF2 gene loci on reproduction, milk yield and lameness of Holstein cows. Research in Veterinary Science. 2011;91(2):235-239. Available from: https://pubmed.ncbi.nlm.nih.gov/21310447/
Michel-Regalado NG, Ayala-Valdovinos MÁ, Galindo-Garcia J, Duifhuis-Rivera T, Sánchez-Chiprés DR, Valencia-Posadas M. Effect of COQ9 and STAT5A polymorphisms on reproductive performance in a Holstein cow herd in Mexico. Animal Reproduction. 2020;17(3): e20200039. Available from: https://www.animal-reproduction.org/article/doi/10.1590/1984-3143-AR2020-0039
Etherton TD, Bauman DE. Biology of Somatotropin in Growth and Lactation of Domestic Animals. Physiological Reviews. 1998;78:745–61. Available from: https://pubmed.ncbi.nlm.nih.gov/9674693/
Lucy MC, McDougall S, Nation DP. The use of hormonal treatments to improve the reproductive performance of lactating dairy cows in feedlot or pasture-based management systems. Animal Reproduction Science. 2004;82-83:495-512. Available from: https://pubmed.ncbi.nlm.nih.gov/15271476/
Pryce JE, Royal MD, Garnsworthy PC, Mao IL. Fertility in the high-producing dairy cow. Livestock Production Science. 2004; 86(1-3):125–135. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0301622603001453
Aggrey SE, Yao J, Sabour MP, Lin CY, Zadworny D, Hayes JF, Kuhnlein U. Markers within the regulatory region of the growth hormone receptor gene and their association with milk-related traits in Holsteins. The Journal of heredity. 1999;90(1):148–151. Available from: https://pubmed.ncbi.nlm.nih.gov/9987923/
Pinedo PJ, De Vries A. Effect of days to conception in the previous lactation on the risk of death and live culling around calving. Journal of dairy science. 2010;93(3):968-77. Available from: https://pubmed.ncbi.nlm.nih.gov/20172217/
Shirasuna K, Kawashima C, Murayama C, et al. Relationships between the first ovulation postpartum and polymorphism in genes relating to function of immunity, metabolism and reproduction in high-producing dairy cows. The Journal of reproduction and development. 2011;57(1):135-142. Available from: https://pubmed.ncbi.nlm.nih.gov/21071888/
Butler ST, Pelton SH, Butler WR. Insulin increases 17 beta-estradiol production by the dominant follicle of the first postpartum follicle wave in dairy cows. Reproduction. 2004;127(5):537-545. Available from: https://pubmed.ncbi.nlm.nih.gov/15129009/
Homer EM, Derecka K, Webb R, Garnsworthy PC. Mutations in genes involved in oestrous cycle associated expression of oestrus. Animal Reproduction Science. 2013;142(3-4):106–112. Available from: https://pubmed.ncbi.nlm.nih.gov/24139696/
Bergamaschi MACM, Machado R, Barbosa RT. Eficiência reprodutiva das vacas leiteiras. Circular técnico – EMBRAPA, São Carlos-SP, 2010. Available from: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/880245
Kawashima C, Munakata M, Shimizu T, Miyamoto A, Kida K, Matsui M. Relationship between the degree of insulin resistance during late gestation and postpartum performance in dairy cows and factors that affect growth and metabolic status of their calves. The Journal of Veterinary Medical Science. Available from: 2016;78(5):739-745. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905825/
Clempson A, Pollott GE, Brickell JS, Wathes DC. Associations Between Bovine IGFBP2 Polymorphisms with Fertility, Milk Production, and Metabolic Status in UK Dairy Cows. Animal Biotechnology. 2012;23(2):101-13. Available from: https://www.tandfonline.com/doi/full/10.1080/10495398.2011.650775
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