Comparison of the activity of fatty essential acids and biomembrane in the microbiota of infected chronic wounds

Abstract

For patients cured of leprosy, low-limb ulcers represent a challenge to healthcare workers, for being chronic, infected, and recurrent. This study aimed to compare the latex biomembrane (Biocure™) and an EFA-based product (Dersani™) action on the microbiota of infected chronic wounds, in patients discharged from the treatment of leprosy. This is a research carried out at Hospital de Dermatologia Sanitária, in Goiânia-GO, from February to October 2007, in which 8 individuals cured of leprosy, having 19 infected wounds, were randomly allocated in group A (Dersani ™) and group B (Biocure™). Staphylococcus aureus (50%), Pseudomonas aeruginosa (35.7%), Proteus vulgaris (8.2%), Enterobacter aerogenes (3.3%), and Escherichia coli  (2.7%) were isolated. The results obtained in vivo suggest that Dersani™ has a positive antimicrobial effect against Enterobacter aerogenes and Biocure™ against Pseudomonas aeruginosa, despite the in vitro results having shown absence of antimicrobial activity for both products against microorganisms standard and isolated from the wounds.