Adverse events following human papillomavirus vaccine in adolescents: systematic review of the literature

Authors

  • Bianca Maria Oliveira Luvisaro Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: biancaluvisaro@hotmail.com. https://orcid.org/0000-0002-6093-2956
  • Thales Philipe Rodrigues da Silva Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: thalesphilipe27@hotmail.com. https://orcid.org/0000-0002-7115-0925
  • Ana Paula Vieira Faria Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: anapaulavieira87@yahoo.com.br. https://orcid.org/0000-0002-9191-2990
  • Camila Kümmel Duarte Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: camila.kummel@gmail.com. https://orcid.org/0000-0003-1930-3282
  • Tércia Moreira Ribeiro da Silva Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: tercialud@gmail.com. https://orcid.org/0000-0002-5261-2266
  • Adalton Elérito Satil Neto Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: neto.adalton@gmail.com. https://orcid.org/0000-0002-6854-5635
  • Natatia Santana Carvalho Secretaria de Estado de Saúde de Minas Gerais (SESMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: natatiasilva87@gmail.com. https://orcid.org/0000-0003-4409-2093
  • Fernanda Penido Matozinhos Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brasil. E-mail: nandapenido@hotmail.com. https://orcid.org/0000-0003-1368-4248

DOI:

https://doi.org/10.5216/ree.v26.76182

Keywords:

Vaccination, Human Papillomavirus Viruses, Adolescent, Drug-Related Side Effects and Adverse Reactions, Injection Site Reaction

Abstract

Objective: The objective of this study was to investigate the occurrence of Events Supposedly Attributable to Vaccination and/or Immunization associated with the Human Papillomavirus vaccine among adolescents of both sexes. Methods: This is a systematic review carried out according to the principles of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Results: Initially, 11,016 articles were identified, of which 6,824 remained after removing duplicates, and 59 of these were selected for full reading. The sample comprised nine studies. The results indicate that most Events Supposedly Attributable to Vaccination and/or Immunization were mild and moderate, and events at the injection site, such as pain and edema, prevailed. The most common systemic Events Supposedly Attributable to Vaccination and/or Immunization were fever, headache, fatigue and dizziness. Conclusion: The Human Papillomavirus vaccine for adolescents is safe, reinforcing its importance as a strategy to reduce the incidence rates of Human Papillomavirus associated cancers.

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Published

2024-05-30

Issue

Vol. 26 (2024)

Section

Review Article

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