Ineffective protection in patients undergoing hematopoietic stem cell transplantation: concept analysis

Authors

  • Kilders Mitshel Lucas de Oliveira Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brasil, kildersmit@gmail.com. https://orcid.org/0000-0002-3868-1345
  • Thaynan Gonçalves da Silva Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brasil, t.thaygoncalves@gmail.com. https://orcid.org/0000-0003-4300-8304
  • Jaqueline Galdino Albuquerque Perrelli Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brasil, jaqueline.albuquerque@ufpe.br.  https://orcid.org/0000-0003-4934-1335
  • Sheila Coelho Ramalho Vasconcelos Morais Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brasil, sh25crvm@gmail.com.
  • Francisca Márcia Pereira Linhares Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brasil, francisca.linhares@ufpe.br.
  • Suzana de Oliveira Mangueira Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brasil, suzana.mangueira@ufpe.br. https://orcid.org/0000-0003-0931-8675

DOI:

https://doi.org/10.5216/ree.v23.65852

Keywords:

Nursing Diagnosis, Protection, Hematopoietic Stem Cells

Abstract

The objective was to analyze the “Protection” concept in patients undergoing hematopoietic stem cell transplantation and correlate it with elements of the “Ineffective Protection” nursing diagnosis proposed by NANDA-I. Integrative literature review based on the Concept Analysis model proposed by Walker and Avant and performed at the Virtual Health Library and CINAHL, SCOPUS, PUBMED/MEDLINE, LILACS and Web of Science databases within a five-year time frame . The final sample consisted of 16 articles and the identification of three defining attributes, 15 antecedents and 11 consequences. Conclusion: concept analysis can contribute to refine and improve the nursing diagnosis “Ineffective Protection”. It was possible to identify another definition, 10 antecedents and 10 consequences that are not included in NANDA-I, as well as the need to revise the definition and other components of the diagnosis proposed by the taxonomy.

Downloads

Download data is not yet available.

References

Wildes TM, Stirewalt DL, Medeiros B, Hurria A. Hematopoietic Stem Cell Transplantation for Hematologic Malignancies in Older Adults: Geriatric Principles in the Transplant Clinic. Natl Compr Cancer Netw J Natl Compr Canc Netw [Internet]. 2014 [acesso em: 22 mar. 2021];12(1):128-36. Disponível em: https://doi.org/10.6004/jnccn.2014.0010.

Henig I, Zuckerman T. Hematopoietic stem cell transplantation-50 years of evolution and future perspectives. Rambam Maimonides Med J [Internet]. 2014 [acesso em: 22 mar. 2021];5(4):e0028. Disponível em: https://doi.org/10.5041/RMMJ.10162.

Sureda A, Bader P, Cesaro S, Dreger P, Duarte RF, Dufour C, et al. Indications for allo- and auto-SCT for hematological diseases, solid tumours and immune disorders: current practice in Europe, 2015. Bone Marrow Transplant [Internet]. 2015 [acesso em: 22 mar. 2021];50(8):1037-56. Disponível em: https://doi.org/10.1038/bmt.2015.6.

Dimensionamento dos Transplantes no Brasil e em cada estado (2012-2019): Registro Brasileiro de Transplantes [Internet]. Brasil: Associação Brasileira de Transplante de Órgãos; 2020 [revised 2020 Aug 29; cited 2020 Aug 29]. Available from: http://www.abto.org.br/abtov03/Upload/file/RBT/2019/RBT-2019-leitura.pdf.

Schmitz F, Wolf D, Holderried TAW. The Role of Immune Checkpoints after Cellular Therapy. Int J Mol Sci [Internet]. 2020 [acesso em: 22 mar. 2021];21(10):3650. Disponível em: https://doi.org/10.3390/ijms21103650.

Zaghi E, Calvi M, Di Vito C, Mavilio D. Innate Immune Responses in the Outcome of Haploidentical Hematopoietic Stem Cell Transplantation to Cure Hematologic Malignancies. Front Immunol [Internet]. 2019 [acesso em: 22 mar. 2021];10:2794. Disponível em: https://doi.org/10.3389/fimmu.2019.02794.

Hockenbery DM, Strasser SI, McDonald GB. Gastrointestinal and hepatic complications. In: Forman SJ, Negrin RS, Antin JH, Appelbaum FR, eds. Thomas’ Hematopoietic Cell Transplantation. 5th ed. Chichester, West Sussex, United Kingdom: John Wiley & Sons Ltd; 2015. p. 1140-60.

Carreras E, Diaz-Ricart M. The role of the endothelium in the short-term complications of hematopoietic SCT. Bone Marrow Transplant [Internet]. 2011 [acesso em: 22 mar. 2021];46(12):1495-502. Disponível em: https://doi.org/10.1038/bmt.2011.65.

González de Villamborsia IF. Manejo enfermero del paciente pediátrico durante el trasplante de médula ósea. Aspectos emocionales y sociales más importantes. Nuberos Científica [Internet]. 2014 [acesso em: 13 abr. 2021];2(12):28-35. Disponível em: http://enfermeriacantabria.com/web_enfermeriacantabria/docs/Revista_Nuberos_Cien_2.pdf.

Guimarães CS, Silveira RCCP, Nilsen L, Rodrigues MCO. Transplante autólogo de células-tronco hematopoéticas para esclerose sistêmica: ações de enfermagem. Rev. Eletr. Enferm. [Internet]. 2014 [acesso em: 22 mar. 2021];16(1):77-83. Disponível em: https://doi.org/10.5216/ree.v16i1.20962.

Lima K, Bernardino E. Nursing care in a hematopoietic stem cells transplantation unit. Texto contexto - enferm. [Internet]. 2014 [acesso em: 22 mar. 2021];23(4):845-53. Disponível em: https://doi.org/10.1590/0104-07072014000440013.

Yilmaz FT, Sabanciogullari S, Aldemir K. The Opinions of Nursing Students Regarding the Nursing Process and Their Levels of Proficiency in Turkey. J Caring Sci [Internet]. 2015 [acesso em: 22 mar. 2021];4(4):265-75. Disponível em: https://doi.org/10.15171/jcs.2015.027.

Medeiros AL, Santos SR, Cabral RWL. Sistematização da assistência de enfermagem na perspectiva dos enfermeiros: uma abordagem metodológica na teoria fundamentada. Rev Gaúcha Enferm [Internet]. 2012 [acesso em: 22 mar. 2021];33(3):174-81. Disponível em: https://doi.org/10.1590/S1983-14472012000300023.

Herdman H, Kamitsuru S. Diagnósticos de enfermagem da NANDA: definições e classificação 2018-2020. 11ª ed. Porto Alegre: Artmed; 2018.

Lima K, Bernardino E, Wolff LDG, Peres AM. Características da produção científica de enfermagem em transplante de células-tronco hematopoiéticas. Cogitare Enfermagem [Internet]; 2012 [acesso em: 22 mar. 2021];17(3):568-73. Disponível em: https://doi.org/10.5380/ce.v17i3.21274.

Mcewen M, Wills EM. Bases teóricas para a enfermagem: os fundamentos à prática profissional. 2ª ed. Porto Alegre: Artmed; 2009.

Walker LO, Avant KC. Strategies for theory construction in nursing. 4th ed. Upper Saddle River: Prentice Hall; 2005.

Walker LO, Avant KC. Strategies for Theory Construction in Nursing. 5th ed. Upper Saddle River: Pearson/Prentice Hall; 2011.

Whittemore R, Knafl K. The integrative review: updated methodology. J Adv Nurs [Internet]. 2005 [acesso em: 22 mar. 2021];52(5):546-53. Disponível em: https://doi.org/10.1111/j.1365-2648.2005.03621.x.

The Joanna Briggs Institute. The Joanna Briggs Institute Reviewers’ Manual 2014. The Systematic Review of Economic Evaluation Evidence [Internet] Adelaiade: The Joanna Briggs Institute; 2014 [acesso em: 22 mar. 2021]. Disponível em: https://nursing.lsuhsc.edu/JBI/docs/ReviewersManuals/Economic.pdf.

Melnyk B M, Fineout-Overholt E. Evidence-based practice in nursing & healthcare: a guide to best practice. Philadelphia: Lippincott Williams & Wilkins; 2010.

CASP UK. CASP Checklists [Internet]. Oxford, UK: CASP UK - OAP Ltd., c2021 [acesso em: 13 abr. 2021]. Disponível em: https://casp-uk.net/casp-tools-checklists/.

Loeff FC, Falkenburg JHF, Hageman L, Huisman W, Veld SAJ, van Egmond HME, et al. High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor−/CD52− T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell–Depleted Allogeneic Stem Cell Transplantation. J Immunol [Internet]. 2018 [acesso em: 23 mar. 2021];200(6):2199-208. Disponível em: https://doi.org/10.4049/jimmunol.1701018.

Krawczyk A, Ackermann J, Goitowski B, Trenschel R, Ditschkowski M, Timm J, et al. Assessing the risk of CMV reactivation and reconstitution of antiviral immune response post bone marrow transplantation by the QuantiFERON-CMV-assay and real time PCR. J Clin Virol [Internet]. 2018 [acesso em: 23 mar. 2021];99-100: 61-6. Disponível em: https://doi.org/10.1016/j.jcv.2018.01.002.

Poiret T, Axelsson-Robertson R, Remberger M, Luo XH, Rao M, Nagchowdhury A, et al. Cytomegalovirus-Specific CD8+ T-Cells With Different T-Cell Receptor Affinities Segregate T-Cell Phenotypes and Correlate With Chronic Graft-Versus-Host Disease in Patients Post-Hematopoietic Stem Cell Transplantation. Front Immunol [Internet]. 2018 [acesso em: 23 mar. 2021];9:760. Disponível em: https://doi.org/10.3389/fimmu.2018.00760.

Gary R, Aigner M, Moi S, Schaffer S, Gottmann A, Maas S, et al. Clinical-grade generation of peptide-stimulated CMV/EBV-specific T cells from G-CSF mobilized stem cell grafts. J Transl Med [Internet]. 2018 [acesso em: 24 mar. 2021],16(1):124. Disponível em: https://doi.org/10.1186/s12967-018-1498-3.

Sahoo F, Hill JA, Xie H, Leisenring W, Yi J, Goyal S, et al. Herpes zoster in autologous hematopoietic cell transplant recipients in the era of acyclovir or valacyclovir prophylaxis and novel treatment and maintenance therapies. Biol Blood Marrow Transplant [Internet]. 2017 [acesso em: 24 mar. 2021]; 23(3):505-11. Disponível em: https://doi.org/10.1016/j.bbmt.2016.12.620.

Tzannou I, Papadopoulou A, Naik S, Leung K, Martinez CA, Ramos CA, et al. Off-the-shelf virus-specific T cells to treat BK virus, human herpesvirus 6, cytomegalovirus, Epstein-Barr virus, and adenovirus infections after allogeneic hematopoietic stem-cell transplantation. J Clin Oncol [Internet]. 2017 [acesso em: 23 mar. 2021]; 35(31):3547-57. Disponível em: https://doi.org/10.1200/JCO.2017.73.0655.

Bollard CM, Heslop HE. T cells for viral infections after allogeneic hematopoietic stem cell transplant. Blood [Internet]. 2016 [acesso em: 23 mar. 2021];127(26):3331-40. Disponível em: https://doi.org/10.1182/blood-2016-01-628982.

L’Huillier AG, Kumar D. Immunizations in solid organ and hematopoeitic stem cell transplant patients: A comprehensive review. Hum Vaccin Immunother [Internet]. 2015 [acesso em: 24 mar. 2021];11(12):2852-63. Disponível em: https://doi.org/10.1080/21645515.2015.1078043.

Roddie C, Peggs KS. Immunotherapy for transplantation-associated viral infections. J Clin Invest [Internet]. 2017 [acesso em: 24 mar. 2021];127(7):2513-22. Disponível em: https://doi.org/10.1172/JCI90599.

Lee YJ, Arguello ES, Jenq RR, Littmann E, Kim GJ, Miller LC, et al. Protective factors in the intestinal microbiome against Clostridium difficile infection in recipients of allogeneic hematopoietic stem cell transplantation. J Infec Dis [Internet]. 2017 [acesso em: 24 mar. 2021];215(7):1117-23. Disponível em: https://doi.org/10.1093/infdis/jix011.

Teshima T, Reddy P, Zeiser R. Reprint of: Acute Graft-versus-Host Disease: Novel Biological Insights. Biol Blood Marrow Transplant [Internet]. 2016 [acesso em: 24 mar. 2021];22(3 Suppl):S3-8. Disponível em: https://doi.org/10.1016/j.bbmt.2016.01.004.

Hayashi H, Kobayashi R, Suzuki A, Yamada Y, Ishida M, Shakui T, et al. Preparation and clinical evaluation of a novel lozenge containing polaprezinc, a zinc-L-carnosine, for prevention of oral mucositis in patients with hematological cancer who received high-dose chemotherapy. Med Oncol [Internet]. 2016 [acesso em: 24 mar. 2021];33(8):91. Disponível em: https://doi.org/10.1007/s12032-016-0795-z.

van Leeuwen SJM, Proctor GB, Potting CMJ, ten Hoopen ST, van Groningen LFJ, Bronkhorst EM, Blijlevens NMA, et al. Early salivary changes in multiple myeloma patients undergoing autologous HSCT. Oral Dis [Internet]. 2018 [acesso em: 24 mar. 2021];24(6):972-2. Disponível em: https://doi.org/10.1111/odi.12866.

Cima LN, Colita A, Fica S. Perspectives on the co-treatment with GnRHa in female patients undergoing hematopoietic stem cell transplantation. Endocr Connect [Internet]. 2017 [acesso em: 24 mar. 2021];6(8):R162-70. Disponível em: https://doi.org/10.1530/EC-17-0246.

Sakurai M, Mori T, Kato J, Koda Y, Kikuchi T, Kohashi S, et al. Efficacy of aprepitant in preventing nausea and vomiting due to high-dose melphalan-based conditioning for allogeneic hematopoietic stem cell transplantation. Int J Hematol [Internet]. 2014 [acesso em: 24 mar. 2021];99(4):457-62. Disponível em: https://doi.org/10.1007/s12185-014-1538-6.

Jafari H, Janati Y, Yazdani J, Bali N, Hassanpour S. The effect of relaxation technique on fatigue levels after stem cell transplant. Iran J Nurs Midwifery Res [Internet]. 2018 [acesso em: 24 mar. 2021];23(5):388-94. Disponível em: https://doi.org/10.4103/ijnmr.IJNMR_26_17.

Reis MAL, Visentainer JEL. Reconstituição imunológica após o transplante de medula óssea alogênico. Rev. Bras. Hematol. Hemoter. [Internet]. 2004 [acesso em: 24 mar. 2021];26(3):212-7. Disponível em: https://doi.org/10.1590/S1516-84842004000300012.

André I, Simons L, Ma K, Moirangthem RD, Diana JS, Magrin E, et al. Ex vivo generated human T-lymphoid progenitors as a tool to accelerate immune reconstitution after partially HLA compatible hematopoietic stem cell transplantation or after gene therapy. Bone Marrow Transplant [Internet]. 2019 [acesso em: 24 mar. 2021];54(2):749-55. Disponível em: https://doi.org/10.1038/s41409-019-0599-9.

Severyn CJ, Brewster R, Andermann TM. Microbiota modification in hematology: still at the bench or ready for the bedside? Blood Adv [Internet]. 2019 [acesso em: 24 mar. 2021];3(21):3461-72. Disponível em: https://doi.org/10.1182/bloodadvances.2019000365.

Pereira WA, coord. Diretrizes básicas para captação e retirada de múltiplos órgãos e tecidos da Associação Brasileira de Transplante de Órgãos [Internet]. São Paulo: ABTO; 2009 [acesso em: 13 abr. 2021]. Disponível em: http://www.abto.org.br/abtov03/Upload/pdf/livro.pdf.

Saboya R, Lerner D, Alousi A, Dulley FL, Lima M. Regimes Quimioterápicos de Condicionamento para Transplante de Células-Tronco Hematopoéticas. In: Voltarelli JC, Pasquini R, Ortega ETT, org. Transplante de Células-Tronco Hematopoéticas. São Paulo: Atheneu; 2009. p. 527-53.

Hamerschlak N, Bouzas LFDS, Seber A, Silla L, Ruiz MA, editores. Diretrizes da Sociedade Brasileira de Transplante de Medula Óssea 2012. II Reunião de Diretrizes da Sociedade Brasileira de Transplante de Medula Óssea Angra dos Reis (RJ), 4 a 6 de maio de 2012 [Internet]. São Paulo: Sociedade Brasileira de Transplante de Medula Óssea; 2013 [acesso em: 24 mar. 2021]. Disponível em: https://www.sbtmo.org.br/userfiles/fck/Diretrizes_da_Sociedade_Brasileira_de_Transplante_de_Medula_Óssea_2012_ISBN_978-85-88902-17-6.pdf.

Santos KB, Ribeiro LC, Silva GA, Atalla A, Hallack Neto AE. Medidas não medicamentosas para a prevenção de infecção no Transplante de Medula óssea: revisão da literatura. HU Revista [Internet]. 2011 [acesso em: 24 mar. 2021];37(2):239-46. Disponível em: https://periodicos.ufjf.br/index.php/hurevista/article/view/1216.

Lim WA, June CH. The principles of engineering immune cells to treat cancer. Cell [Internet]. 2017 [acesso em: 24 mar. 2021];168(4):724-40. Disponível em: https://doi.org/10.1016/j.cell.2017.01.016.

Ariza-Heredia EJ, Gulbis AM, Stolar KR, Kebriaei P, Shah DP, McConn KK, et al. Vaccination guidelines after hematopoietic stem cell transplantation: practitioners’ knowledge, attitudes, and gap between guidelines and clinical practice. Transpl Infect Dis [Internet]. 2014 [acesso em: 24 mar. 2021];16(6):878-86. Disponível em: https://doi.org/10.1111/tid.12312.

Cordonnier C, Ljungman P, Juergens C, Maertens J, Selleslag D, Sundaraiyer V, et al. Immunogenicity, Safety, and Tolerability of 13-Valent Pneumococcal Conjugate Vaccine Followed by 23-Valent Pneumococcal Polysaccharide Vaccine in Recipients of Allogeneic Hematopoietic Stem Cell Transplant Aged ≥2 Years: An Open-Label Study. Clin Infect Dis [Internet]. 2015 [acesso em: 24 mar. 2021];61:313-23. Disponível em: https://doi.org/10.1093/cid/civ287.

Rubin LG, Levin MJ, Ljungman P, Davies EG, Avery R, Tomblyn M, et al. IDSA clinical practice guideline for vaccination of the immunocompromised host. Clin Infect Dis [Internet]. 2014 [acesso em: 24 mar. 2021];58(3):309-18. Disponível em: https://doi.org/10.1093/cid/cit816.

Morishita T, Tsushita N, Imai K, Sakai T, Miyao K, Sakemura R, et al . The Efficacy of an Oral Elemental Diet in Patients Undergoing Hematopoietic Stem Cell Transplantation. Intern Med [Internet]. 2016 [acesso em: 24 mar. 2021];55(24):3561-69. Disponível em: https://doi.org/10.2169/internalmedicine.55.7310.

Baysal E, Sari D. Effects of cryotherapy in preventing oral mucositis in hematopoietic stem cell transplantation patients: Literature review. Complement Ther Clin Pract [Internet]. 2019 [acesso em: 24 mar. 2021];35:342-7. Disponível em: https://doi.org/10.1016/j.ctcp.2019.03.017.

Baydoun M, Barton DL. Complementary therapies for fatigue after hematopoietic stem cell transplantation: an integrative review. Bone Marrow Transplant [Internet]. 2018 [acesso em: 24 mar. 2021];53(5):556-64. Disponível em: https://doi.org/10.1038/s41409-017-0073-5.

Cho SK, McCombs J, Punwani N, Lam J. Complications and hospital costs during hematopoietic stem cell transplantation for non-Hodgkin lymphoma in the United States. Leuk Lymphoma [Internet]. 2019 [acesso em: 24 mar. 2021];60(10):2464-70. Disponível em: https://doi.org/10.1080/10428194.2019.1581932.

Yu J, Parasuraman S, Shah A, Weisdorf D. Mortality, length of stay and costs associated with acute graft-versus-host disease during hospitalization for allogeneic hematopoietic stem cell transplantation. Curr Med Res Opin [Internet]. 2019 [acesso em: 24 mar. 2021];35(6):983-8. Disponível em: https://doi.org/10.1080/03007995.2018.1551193.

Bevans MF, Mitchell SA, Marden S. The symptom experience in the first 100 days following allogeneic hematopoietic stem cell transplantation (HSCT). Support Care Cancer [Internet]. 2008 [acesso em: 24 mar. 2021];16(11):1243-54. Disponível em: https://doi.org/10.1007/s00520-008-0420-6.

Marques ACB, Proença SFFS, Machado CAM, Guimarães PRB, Maftum MA, Kalinke LP. Qualidade de vida nos primeiros seis meses pós-transplante de células-tronco hematopoéticas. Texto contexto - enferm. [Internet]. 2017 [acesso em: 24 mar. 2021];26(3):e5040016. Disponível em: https://doi.org/10.1590/0104-07072017005040016.

Downloads

Published

2021-05-26

Issue

Vol. 23 (2021)

Section

Review Article

License

Copyright (c) 2021 Revista Eletrônica de Enfermagem

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.