Drug resistance evolution of Pseudomonas aeruginosa and Acinetobacter baumannii in intensive care units

Authors

  • Marciano de Sousa Nóbrega Universidade Federal de Goiás, Hospital das Clínicas
  • José Rodrigues do Carmo Filho Pontifícia Universidade Católica de Goiás
  • Milca Severino Pereira Pontifícia Universidade Católica de Goiás

DOI:

https://doi.org/10.5216/ree.v15i3.22031

Keywords:

Pseudomonas aeruginosa, Acinetobacter baumannii, Drug Resistance, Anti-Infective Agents, Cross Infection

Abstract

ABSTRACT

The objective of this study was to describe the susceptibility of A. baumannii and P. aeruginosa, analyze the trend in bacterial resistance and use of antimicrobial agents. This retrospective, descriptive, cross-sectional study was performed in the adult intensive care units of a large-scale public teaching hospital, within the Brazilian Unified Health System (SUS). A total of 121 cases of infection by P. aeruginosa and A. baumannii were identified. A high mean initial resistance rate was observed for both microorganisms. A significant increase was observed in resistance to amikacin in A. baumannii. There was an increase in the consumption of amikacin, imipenem, and piperacillin-tazobactam in P. aeruginosa infections, and of imipenem in A. baumannii infections. No correlation was found between bacterial resistance and antimicrobial use. Higher mortality rates and longer length of stay were observed in the studied group, and bacterial resistance was high. Furthermore, there was an increase in the use of amikacin, imipenem and piperacillin-tazobactam.

Descriptors: Pseudomonas aeruginosa; Acinetobacter baumannii; Drug Resistance; Anti-Infective Agents; Cross Infection.

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Author Biographies

Marciano de Sousa Nóbrega, Universidade Federal de Goiás, Hospital das Clínicas

Médico, Mestre em Ciências Ambientais e Saúde. Médico do Hospital das Clínicas da Universidade Federal de Goiás. Goiânia, GO, Brasil. E-mail: marcianosousa@terra.com.br.

José Rodrigues do Carmo Filho, Pontifícia Universidade Católica de Goiás

Enfermeiro e Biomédico, Doutor em Microbiologia Clínica. Docente da Pontifícia Universidade Católica de Goiás (PUC-GO). Goiânia, GO, Brasil. E-mail: biomedico53@gmail.com.

Milca Severino Pereira, Pontifícia Universidade Católica de Goiás

Enfermeira, Doutora em Enfermagem. Docente da PUC-GO. Goiânia, GO, Brasil. E-mail: milcaseverino@gmail.com.

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Published

2013-09-30

How to Cite

1.
Nóbrega M de S, Carmo Filho JR do, Pereira MS. Drug resistance evolution of Pseudomonas aeruginosa and Acinetobacter baumannii in intensive care units. Rev. Eletr. Enferm. [Internet]. 2013 Sep. 30 [cited 2024 Jul. 18];15(3):694-701. Available from: https://revistas.ufg.br/fen/article/view/22031

Issue

Vol. 15 No. 3 (2013)

Section

Original Article