Evaluation of total serum antibodies against phenolic glycolipid-1 (PGL-1) of Mycobacterium leprae in individuals with Hansen disease and their house contacts in the State of Goias, Brazil

Authors

  • Bruna Daniella de Souza Silva
  • Marise Ramos de Souza
  • Thereza Liberman Kipnis
  • Ana Paula Paula Junqueira-Kipnis

DOI:

https://doi.org/10.5216/rpt.v38i3.7837

Keywords:

Mycobacterium leprae, ELISA, Antibodies anti-PGL-1, Leprosy, Household contacts.

Abstract

Leprosy is a chronic disease caused by Mycobacterium leprae, an obligatory
intracellular bacillus that infects preferentially skin macrophages and Schwann
cells of peripheral nerves. The diagnosis of the disease is complex as there are
several clinical manifestations. New diagnostic tests aiming the control of disease transmission are being pursued, among which we highlight the dosage of IgM
anti phenolic glycolipid-1 (PGL-1). Total serum antibodies against PGL-1 in
patients and in their household contacts were evaluated by enzyme immunoassay.
Both patients and their contacts presented detectable levels of anti-PGL-1 in the
serum thus indicating a potential risk of transmission of the disease among these
individuals.

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Published

2009-10-19

How to Cite

SILVA, B. D. de S.; DE SOUZA, M. R.; KIPNIS, T. L.; JUNQUEIRA-KIPNIS, A. P. P. Evaluation of total serum antibodies against phenolic glycolipid-1 (PGL-1) of Mycobacterium leprae in individuals with Hansen disease and their house contacts in the State of Goias, Brazil. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 38, n. 3, p. 187–196, 2009. DOI: 10.5216/rpt.v38i3.7837. Disponível em: https://revistas.ufg.br/iptsp/article/view/7837. Acesso em: 23 nov. 2024.

Issue

Vol. 38 No. 3 (2009)

Section

ORIGINAL ARTICLES

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