ISONIAZID-RESISTANT TUBERCULOUS SPONDYLODISCITIS ASSOCIATED WITH SCROFULODERMA

Authors

  • Luiz Felipe Silveira Sales Tropical Diseases Hospital Dr Anuar Auad, Goiania, Brazil.
  • Murilo Fraga Oliveira Calábria Hospital das Clínicas, UFG, Goiania, Brazil
  • Erika Barcelos Costa Hospital das Clínicas, UFG, Goiania, Brazil
  • Andre Kipnis
  • Moara Alves Santa Bárbara Borges Hospital das Clínicas, UFG, Goiania, Brazil and Institute of Tropical Pathology and Public Health, Federal University of Goiás (UFG) Goiania, Brazil
  • Marta Antunes de Souza Institute of Tropical Pathology and Public Health, Federal University of Goiás (UFG) Goiania, Brazil
  • Adriana Oliveira Guilarde Hospital das Clínicas, UFG, Goiania, Brazil and Institute of Tropical Pathology and Public Health, Federal University of Goiás (UFG) Goiania, Brazil

DOI:

https://doi.org/10.5216/rpt.v47i4.56745

Keywords:

Extrapulmonary tuberculosis, tuberculous spondilodiscitis, scrofuloderma.

Abstract

The extrapulmonary forms of tuberculosis are responsible for about 20% of cases. Scrofuloderma is the cutaneous manifestation secondary to infection in some subcutaneous foci. A 33-year-old patient was admitted to the Clinical Hospital with exudative skin lesions on the back and thorax, initiated 10 months previously, associated with daily fever, and constipation. Spine resonance showed a paravertebral pseudotumoral lesion with T4 and T9 invasion, including vertebral canal and sub-ligament extension. The lesions presented fistulas for paravertebral muscles, lung and skin. Polimerase chain reaction (PCR) proved positive for Mycobacterium tubeculosis in the thorax wound secretion, caracterizing tuberculous spondilodiscitis with scrofuloderma. Treatment was initiated with rifampicin, isoniazid, pyrazinamide and ethambutol with important clinical improvement after the first week. The febrile peaks came to an end and there was improvement in the pattern of the cutaneous lesions. The susceptibility test showed resistance to isoniazid.

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Published

2018-12-27

How to Cite

FELIPE SILVEIRA SALES, L.; FRAGA OLIVEIRA CALÁBRIA, M.; BARCELOS COSTA, E.; KIPNIS, A.; ALVES SANTA BÁRBARA BORGES, M.; ANTUNES DE SOUZA, M.; OLIVEIRA GUILARDE, A. ISONIAZID-RESISTANT TUBERCULOUS SPONDYLODISCITIS ASSOCIATED WITH SCROFULODERMA. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 47, n. 4, 2018. DOI: 10.5216/rpt.v47i4.56745. Disponível em: https://revistas.ufg.br/iptsp/article/view/56745. Acesso em: 22 dec. 2024.

Issue

Vol. 47 No. 4 (2018)

Section

CASE REPORT

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