ASSOCIATION BETWEEN THE IL28B rs12979860 POLYMORPHISM AND THERAPY RESPONSE IN PATIENTS INFECTED WITH GENOTYPE 1 OF HEPATITIS C VIRUS IN CENTRAL BRAZIL

Authors

  • Ágabo Macedo da Costa e Silva
  • Rodrigo Sebba Aires
  • Sueli Meira da Silva
  • Márcia Alves Dias de Matos
  • Megmar Aparecida dos Santos Carneiro
  • Carmen Luci Rodrigues Lopes
  • Sheila Araújo Teles
  • Regina Maria Bringel Martins

DOI:

https://doi.org/10.5216/rpt.v45i2.42013

Keywords:

IL28B, rs12979860, hepatitis C treatment, sustained virological response.

Abstract

Single nucleotide polymorphisms (SNPs) upstream of the IL28B gene have been associated with the spontaneous clearance of hepatitis C virus (HCV) and with a sustained virological response (SVR) to HCV infection treatment. This study aimed to investigate the association between IL28B SNP rs12979860 and SVR in patients with hepatitis C in Central Brazil. A total of 101 HCV genotype 1 mono-infected chronic patients treated with pegylated interferon and ribavirin (PEG-IFN/RBV) were studied in the City of Goiânia, Central Brazil. Analysis of rs12979860 showed that the most prevalent genotype was CT (57.4%), followed by CC (23.8%) and TT (18.8%). An overall SVR rate of 28.7% (95% CI: 20.4-38.7) was found in the study population. In a multivariate analysis, only IL28B rs12979860 CC genotype (OR: 3.77; 95% CI: 1.13-12.60; p = 0.031) was independently associated with SVR. These findings show that IL28B SNP rs12979860 is a strong predictor of SVR in the PEG-IFN/ RBV treatment in patients infected with genotype 1 of HCV in Central Brazil.

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Published

2016-06-14

How to Cite

DA COSTA E SILVA, Ágabo M.; AIRES, R. S.; DA SILVA, S. M.; DE MATOS, M. A. D.; CARNEIRO, M. A. dos S.; LOPES, C. L. R.; TELES, S. A.; MARTINS, R. M. B. ASSOCIATION BETWEEN THE IL28B rs12979860 POLYMORPHISM AND THERAPY RESPONSE IN PATIENTS INFECTED WITH GENOTYPE 1 OF HEPATITIS C VIRUS IN CENTRAL BRAZIL. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 45, n. 2, p. 152–160, 2016. DOI: 10.5216/rpt.v45i2.42013. Disponível em: https://revistas.ufg.br/iptsp/article/view/42013. Acesso em: 21 nov. 2024.

Issue

Vol. 45 No. 2 (2016)

Section

ORIGINAL ARTICLES

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