PLANTS OF THE BRAZILIAN AMAZON WITH POTENTIAL IN VITRO ANTILEISHMANIA ACTIVITY

Authors

  • Dionatas Ulises de Oliveira Meneguetti Programa de Pós Graduação em Biologia Experimental da Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brasil e Laboratório de Fisiofarmacologia da Universidade Federal do Acre (UFAC), Rio Branco, AC, Brasil.
  • Renato Abreu Lima Programa de Pós Graduação em Biodiversidade e Biotecnologia da Amazônia Legal (Rede Bionorte), Manaus, AM, Brasil
  • Sharon Rose Aragão Macedo Programa de Pós Graduação em Biologia Experimental da Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brasil
  • Neuza Biguinati de Barros Programa de Pós Graduação em Biodiversidade e Biotecnologia da Amazônia Legal (Rede Bionorte), Manaus, AM, Brasil
  • João Bezerra Facundo Departamento de Química da UNIR, Porto Velho, RO, Brasil
  • Júlio Sancho Linhares Teixeira Militão Departamento de Química da UNIR, Porto Velho, RO, Brasil
  • Roberto Nicolete Programa de Pós Graduação em Biologia Experimental da Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brasil
  • Valdir Alves Facundo Programa de Pós Graduação em Biologia Experimental da Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brasil

DOI:

https://doi.org/10.5216/rpt.v44i4.39236

Keywords:

Leishmaniasis, chemotherapy, ethnopharmacology.

Abstract

The need to find new drugs for the treatment of leishmaniasis is increasing due to the toxicity of existing drugs and an increase in parasite resistance, which is a threat to disease control. The present study describes a literature review on the plants of the Brazilian Amazon with potential antileishmania activity in vitro. A great diversity of plant species in the Brazilian Amazon was found with potential for research on new herbal therapies and secondary metabolites with leishmanicidal activity, in addition to treatment of other neglected parasitic diseases. This review showed that the species of the genera Casearia, Croton and Physalis are strong candidates in the search for new drugs, because both had an IC50 lower than 1 mg/mL in in vitro tests against promastigotes or amastigotes of Leishmania spp. Further studies of species that have terpenoid or steroids metabolites may also be indicated, due to the antileishmanial potential that they demonstrate.

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Published

2015-12-28

How to Cite

MENEGUETTI, D. U. de O.; LIMA, R. A.; MACEDO, S. R. A.; DE BARROS, N. B.; FACUNDO, J. B.; MILITÃO, J. S. L. T.; NICOLETE, R.; FACUNDO, V. A. PLANTS OF THE BRAZILIAN AMAZON WITH POTENTIAL IN VITRO ANTILEISHMANIA ACTIVITY. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 44, n. 4, p. 359–374, 2015. DOI: 10.5216/rpt.v44i4.39236. Disponível em: https://revistas.ufg.br/iptsp/article/view/39236. Acesso em: 26 jun. 2024.

Issue

Vol. 44 No. 4 (2015)

Section

UP TO DATE

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