ASPERGILLOSIS OF THE NOSE AND PARANASAL SINUSES: A REVIEW OF 54 CASES

Authors

  • Isabel Cristina Espíndola Cardoso Programa de Pós-Graduação em Ciências Pneumológicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Brasil.
  • Flávio de Mattos Oliveira Laboratório de Micologia, Hospital Santa Rita, Irmandade Santa Casa de Misericórdia (ISCMPA), Porto Alegre, RS, Brasil.
  • Cecília Bittencourt Severo Laboratório de Micologia, Hospital Santa Rita, Irmandade Santa Casa de Misericórdia (ISCMPA), Porto Alegre, RS, Brasil. e Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA).
  • Mariana Lunardi Spader Bolsista de Iniciacão Científica PIBIC-FAPERGS-UFRGS
  • Elizabeth Araújo Coordenadora do Núcleo de Otorrinolaringologia do Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.
  • Bruno Hochhegger Serviço de Radiologia, ISCMPA, RS, Brasil.
  • Klaus Loureiro Irion Department of Tropical Medicine, Liverpool Heart and Chest Hospital, Liverpool University, United Kingdom.
  • Luiz Carlos Severo Laboratório de Micologia, Hospital Santa Rita, Irmandade Santa Casa de Misericórdia (ISCMPA), Porto Alegre, RS, Brasil.

DOI:

https://doi.org/10.5216/rpt.v44i1.34819

Keywords:

Paranasal sinuses, Aspergillus, Mycology, Aspergillosis.

Abstract

Aspergillus species are considered opportunistic fungi of increasing clinical importance. Informationregarding extrapulmonary involvement is scarce. The aim of this study was to isolate the differentspecies of Aspergillus from patients with rhinosinusitis. A retrospective study was conducted ina university hospital in Porto Alegre, Brazil (1986–2014). For mycological diagnoses, paranasaltissue obtained at surgery was subjected to histopathology examination and sent for fungal cultures.Of the 54 samples analyzed, 32 were diagnosed positive by culture. The underlying causes ofimmunodeficiency were: six with transplantation (three bone marrow,two lung, one kidney) andtwo with hematological disease (one bone marrow neoplasia and two leukemia). In the presentstudy, the clinical manifestations of rhinosinusitis aspergillosis were: 20 allergic reactions, 20fungus balls, and 14 acute invasive cases. The species isolated from the 54 samples were: Aspergillusfumigatus (n=14); A. flavus (n=6); A. niger (n=2); A. terreus (n=1); A. fischeri (n=1); and Aspergillussp., (n=3). Two concomitant species of Aspergillus were observed in two patients: A. fumigatus andA. flavus; and A. fumigatus and A. niger. In four patients, Aspergillus was associated with other fungi. These were: A. flavus and Fusarium, A. fumigatus and Rhyzopus, A. flavus and Mucorales,and Aspergillus sp. and Mucorales. The most common species of Aspergillus that were responsiblefor paranasal sinus infections were A. fumigatus, A. flavus, and A. niger.

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Published

2015-04-02

How to Cite

CARDOSO, I. C. E.; OLIVEIRA, F. de M.; SEVERO, C. B.; SPADER, M. L.; ARAÚJO, E.; HOCHHEGGER, B.; IRION, K. L.; SEVERO, L. C. ASPERGILLOSIS OF THE NOSE AND PARANASAL SINUSES: A REVIEW OF 54 CASES. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 44, n. 1, p. 13–20, 2015. DOI: 10.5216/rpt.v44i1.34819. Disponível em: https://revistas.ufg.br/iptsp/article/view/34819. Acesso em: 12 may. 2024.

Issue

Vol. 44 No. 1 (2015)

Section

ORIGINAL ARTICLES

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