EXPERIMENTAL TOXOPLASMOSIS: EVALUATION OF THE HEPATIC DAMAGE IN MURINES

Authors

  • Miriam Sylvio Laboratory of Host-Parasite Relationship Studies (LAERPH), Tropical Pathology and Public Health Institute, Federal University of Goiás (IPTSP/UFG) – Goiânia, Goiás, GO.
  • Aline Almeida Barbaresco D’Alessandro Laboratory of Host-Parasite Relationship Studies (LAERPH), Tropical Pathology and Public Health Institute, Federal University of Goiás (IPTSP/UFG) – Goiânia, Goiás, GO.
  • Juliana Boaventura Avelar Laboratory of Host-Parasite Relationship Studies (LAERPH), Tropical Pathology and Public Health Institute, Federal University of Goiás (IPTSP/UFG) – Goiânia, Goiás, GO.
  • Marina Clare Vinaud Laboratory of Host-Parasite Relationship Studies (LAERPH), Tropical Pathology and Public Health Institute, Federal University of Goiás (IPTSP/UFG) – Goiânia, Goiás, GO.
  • Ruy de Souza Lino Junior Experimental Pathology Laboratory, Tropical Pathology and Public Health Institute, Federal University of Goias (IPTSP/UFG) – Goiânia, Goiás, GO.
  • José Clecildo Barreto Bezerra Laboratory of Host-Parasite Relationship Studies (LAERPH), Tropical Pathology and Public Health Institute, Federal University of Goiás (IPTSP/UFG) – Goiânia, Goiás, GO.
  • Ana Maria de Castro Laboratory of Host-Parasite Relationship Studies (LAERPH), Tropical Pathology and Public Health Institute, Federal University of Goiás (IPTSP/UFG) – Goiânia, Goiás, GO.

DOI:

https://doi.org/10.5216/rpt.v43i3.32212

Keywords:

Toxoplasma gondii, experimental, enzymes, aminotransferase, lactate dehydrogenase.

Abstract

Toxoplasma gondii is the most common protozoan found in animals and humans and has been found in several of the host’s organs, including the liver. This study aimed to evaluate hepatic injury in experimental toxoplasmosis caused by two strains of T. gondii (RH and Me-49 strains). Biochemical and histopathological analyses were performed. It was possible to detect significant increases in serum levels of AST, ALT and LDH in both infections. The histopathological analysis showed inflammatory infiltration in the Me-49 strain infection and hyperemia and vasodilation in the RH strain infection. The acute infection (RH strain) induced hepatic failure and the death of the host. The chronic infection (ME-49 strain) caused liver damage but not enough to kill the host. Therefore this study validates the importance of biochemical concentrations for the evaluation of the infection, showing the importance of rigorous clinical assessment of T. gondii infected individuals.

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Published

2014-10-09

How to Cite

SYLVIO, M.; D’ALESSANDRO, A. A. B.; AVELAR, J. B.; VINAUD, M. C.; LINO JUNIOR, R. de S.; BEZERRA, J. C. B.; CASTRO, A. M. de. EXPERIMENTAL TOXOPLASMOSIS: EVALUATION OF THE HEPATIC DAMAGE IN MURINES. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 43, n. 3, p. 303–312, 2014. DOI: 10.5216/rpt.v43i3.32212. Disponível em: https://revistas.ufg.br/iptsp/article/view/32212. Acesso em: 24 nov. 2024.

Issue

Vol. 43 No. 3 (2014)

Section

ORIGINAL ARTICLES

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