CLASSIFICATION OF ADHERENCE ABILITY OF CLINICAL ISOLATES OF Candida SPP IN DIFFERENT PATTERNS OF CELL ARRANGEMENTS

Authors

  • Viviane Menezes de Menezes
  • Iven Neylla Farias Vale
  • Silvio Gomes Monteiro
  • Luís Henrique Bastos Gonçalves
  • Patrícia Maria Silva Figueiredo
  • Cristina Andrade Monteiro

DOI:

https://doi.org/10.5216/rpt.v42i3.26931

Keywords:

Adhesion, Candida, Virulence, Patterns of adhesion

Abstract

Adhesion has been identified as a potential virulence factor for developing candidiasis, since it is a primary mechanism of infection, especially in immunocompromised patients. The present study reports on an in vitro adherence assay and the establishment of patterns of adhesion of clinical isolates of Candida from many different anatomical sites, with the goal of comparing this virulence property among these isolates. Adherence ability was quantified in 118 strains of Candida. The results showed that all isolates adhered to coverslips in a species- and strain-dependent manner with C. glabrata showing the lowest and C. tropicalis the highest levels of adhesion. From 93 (79%) isolates with the ability to adhere, 51 (43.3%) showed weak adherence, 25 (21.2%) moderate adherence and 17 (14.4%), a strong adherence ability. Among the strains with the ability to adhere, 44 (47.31%) presented a pattern of localized adherence, 24 (25.8%) showed an aggregative pattern and only 9 (9.7%) had a pseudo-hyphal type. It was found that non C. albicans strains were more adherent than isolates of C. albicans, suggesting higher expression of this property in those species.

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How to Cite

DE MENEZES, V. M.; FARIAS VALE, I. N.; MONTEIRO, S. G.; BASTOS GONÇALVES, L. H.; SILVA FIGUEIREDO, P. M.; MONTEIRO, C. A. CLASSIFICATION OF ADHERENCE ABILITY OF CLINICAL ISOLATES OF Candida SPP IN DIFFERENT PATTERNS OF CELL ARRANGEMENTS. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 42, n. 3, 2013. DOI: 10.5216/rpt.v42i3.26931. Disponível em: https://revistas.ufg.br/iptsp/article/view/26931. Acesso em: 21 nov. 2024.

Issue

Vol. 42 No. 3 (2013)

Section

ORIGINAL ARTICLES

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