Evaluation of the effect of immunosuppressive drugs in the reactivation of chronic murine toxoplasmosis.
DOI:
https://doi.org/10.5216/rpt.v41i2.19330Keywords:
Toxoplasma gondii, ME-49 strain, Immunosuppressive drugs, Reactivation.Abstract
This study evaluated the potential for reactivation of chronic toxoplasmosis in animmunocompromised murine model. To this end, BALB/c mice were orally infected with 20 cysts of Toxoplasma gondii ME-49 strain. After 60 days, the treatment with orally administered immunosuppressive drugs, such as azathioprine and dexamethasone, and cortisone acetate (administered by subcutaneous route) alone or in combination, started. The treatment was maintained for 28 days and afterwards the animals were euthanized and had their blood and organs removed for serological, histopathological and clinical examinations. When the drugs were associated to cortisone acetate, the clinical manifestations presented by the mice suggested
reactivation due to epidermal lesions in 62.5% of the mice when compared to the control group. The results from this study suggest that with the murine model used, the chronic toxoplasmosis reactivation is greatly influenced by the immunosuppressive treatment proposed. In these cases, the clinic manifestations indicative of chronic toxoplasmosis reactivation may be present even before its detection by serological and histopathological methods.
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ALEIXO, F. S.; VASCONCELOS, F. de F.; SOARES, J. D. A. H.; LINO JÚNIOR, R. de S.; GARCIA-ZAPATA, M. T. A. Evaluation of the effect of immunosuppressive drugs in the reactivation of chronic murine toxoplasmosis. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 41, n. 2, 2012. DOI: 10.5216/rpt.v41i2.19330. Disponível em: https://revistas.ufg.br/iptsp/article/view/19330. Acesso em: 16 aug. 2024.
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