Humoral immune response to Mycobacterium tuberculosis rGroES antigen in patients with tuberculosis and their household contacts

Authors

  • Adeliane Castro da Costa UFG
  • Michelle Cristina Guerreiro dos Reis
  • Bruna Daniella de Souza Silva
  • Monalisa Martins Trentini
  • Ana Paula Junqueira-Kipnis

DOI:

https://doi.org/10.5216/rpt.v40i1.13915

Keywords:

Mycobacterium tuberculosis, MtGroEs, ELISA, IgG and IgM, Patients with Tuberculosis, Household contacts.

Abstract

Tuberculosis (TB) remains one of the most important public health problems of
the world, with 8-10 million new cases and 2-3 million deaths each year. About 50
million people are infected with Mycobacterium tuberculosis. In order to develop
immunodiagnostic tests for TB, several antigens have been tested for the humoral
immune response of patients with active TB. ELISA was performed with plasma
samples from 45 patients with pulmonary TB and 172 contacts (96 negative and 76
positive for the tuberculin skin test). The humoral immune response was evaluated through assessment of IgM and IgG antibodies against recombinant Mycobacterium
tuberculosis GroES (MtGroEs). Patients with active pulmonary tuberculosis had
higher levels of IgG anti-rGroEs than healthy individuals, allowing discrimination
between the two groups.

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Published

2011-04-14

How to Cite

COSTA, A. C. da; REIS, M. C. G. dos; SILVA, B. D. de S.; TRENTINI, M. M.; JUNQUEIRA-KIPNIS, A. P. Humoral immune response to Mycobacterium tuberculosis rGroES antigen in patients with tuberculosis and their household contacts. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 40, n. 1, p. 23–34, 2011. DOI: 10.5216/rpt.v40i1.13915. Disponível em: https://revistas.ufg.br/iptsp/article/view/13915. Acesso em: 21 nov. 2024.

Issue

Vol. 40 No. 1 (2011)

Section

ORIGINAL ARTICLES

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