HEPATI C STEREOLOGY OF ACUTE SCHISTO SOMIASIS MANSONI INFECTION IN C57BL/10 AND CBA MICE

Authors

  • José Roberto Machado-Silva
  • Renata Heisler Neves
  • Elaine Cerqueira da Mota
  • Carlos Alberto Mandarim-de-Lacerda

DOI:

https://doi.org/10.5216/rpt.v39i3.12208

Keywords:

Schistosoma mansoni, Stereology, C57BL/10 mice, CBA mice.

Abstract

Previous studies have shown that the outcome of the experimental schistosomiasis mansoni infection depends on the genetic background of the host. To test whether Schistosoma mansoni infected mice strains present different hepatic pathological pattern during acute infection, we examined liver alterations (hepatocytes, sinusoids, and fibrosis), using stereological approach. Changes in liver organization in adult inbreed females C57BL/10 and CBA mice were examined 8 weeks postinfection. Volume density of hepatocytes Vv[h], sinusoids Vv[s] and hepatic fibrosis Vv[fh] were determined by point counting (M42 system-test) and video-microscopy, using light microscopy. In both mouse strains, Vv[h] and Vv[s] were significantly (p<0.05) reduced in comparison to control group. The largest values of Vv[fh] were found in the C57BL/10 strain. We demonstrate that schistosome infection markedly reduced hepatocytes (CBA mice), sinusoids (C57Bl/10), whereas fibrosis was higher in C57BL/10 strain in comparison to that in CBA/ strain.

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Published

2010-10-21

How to Cite

MACHADO-SILVA, J. R.; NEVES, R. H.; MOTA, E. C. da; MANDARIM-DE-LACERDA, C. A. HEPATI C STEREOLOGY OF ACUTE SCHISTO SOMIASIS MANSONI INFECTION IN C57BL/10 AND CBA MICE. Revista de Patologia Tropical / Journal of Tropical Pathology, Goiânia, v. 39, n. 3, p. 201–220, 2010. DOI: 10.5216/rpt.v39i3.12208. Disponível em: https://revistas.ufg.br/iptsp/article/view/12208. Acesso em: 16 aug. 2024.

Issue

Vol. 39 No. 3 (2010)

Section

ORIGINAL ARTICLES

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