PNS009 Baccharis dracunculifolia extract modulates oxygen-dependent and -independent mechanisms of neutrophil activation and exhibits biological stability

Abstract

Neutrophils (PMNs) play an essential role in the defense of the organism against invading microorganisms throughout oxygen-dependent mechanisms (such as the generation of reactive oxygen species - ROS) and oxygen-independent mechanisms (such as degranulation). Despite of the benefits, excessive discharges of the ROS and the granular content can result in tissue damage, which are involved in the pathogenesis of several inflammatory diseases. Therefore, many research groups are trying to find new compounds to reduce excessive neutrophil activation and thus, modulate the inflammatory process. Baccharis dracunculifolia D.C. (Asteraceae), a native plant from Brazil and the most important botanical source of Southeastern Brazilian propolis (known as green propolis), is used in Brazilian folk medicine to treat inflammatory injuries.