BIO013 Pramipexole and selegiline reduce reactive oxygen species production in vitro

Abstract

Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra and motor and non-motor symptoms. Free radicals may play a role in the biochemical events that lead to neuronal death in old age and in neurodegenerative diseases. Furthermore, oxidative stress is apparent in PD. New therapeutic approaches that slow or halt disease progression have been proposed. Antioxidants, free radical scavengers, trophic factors, and monoamine oxidase inhibitors have all been identified as potential agents for the treatment of PD. Analyzing the chemical structure of certain anti-parkinsonian drugs, decided to investigate independent of its anticholinergic or dopaminergic agonism effects. Thus, the aim of this work was to evaluate the in vitro antioxidant potential of Selegiline and Pramipexole.